Benzamide, 4-cyano-N-[(4-methylphenyl)sulfonyl]-

Base Information

• Chemical Name: Benzamide, 4-cyano-N-[(4-methylphenyl)sulfonyl]-
• CAS No.: 851231-92-0
• Molecular Formula: C15H12N2O3S
• Molecular Weight: 300.338
• Mol file: 851231-92-0.mol

Synonyms:

Chemical Property of Benzamide, 4-cyano-N-[(4-methylphenyl)sulfonyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzamide, 4-cyano-N-[(4-methylphenyl)sulfonyl]-

There total 4 articles about Benzamide, 4-cyano-N-[(4-methylphenyl)sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-toluenesulfonyl azide (941-55-9) + 4-cyanobenzoic Acid (619-65-8,333406-09-0) → 4-cyano-N-tosylbenzamide (851231-92-0)

Guidance literature:

With 2-chloro-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane; triethylamine; In chlorobenzene; at 20 - 130 ℃; for 14h; chemoselective reaction;

DOI:10.1002/chem.201201773

Reference yield: 82.0%

4-iodobenzonitrile (3058-39-7) + toluene-4-sulfonamide (70-55-3) + molybdenum hexacarbonyl (13939-06-5,199620-15-0) → 4-cyano-N-tosylbenzamide (851231-92-0)

Guidance literature:

With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; at 115 ℃; for 0.25h; Sealed tube; Microwave irradiation;

DOI:10.1039/c8cc09661a

Reference yield:

4-cyanobenzoyl chlorIde (6068-72-0) + toluene-4-sulfonamide (70-55-3) → 4-cyano-N-tosylbenzamide (851231-92-0)

Guidance literature:

With dmap; triethylamine; In ethyl acetate; toluene; at 55 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c7cc02105d

upstream raw materials:

4-toluenesulfonyl azide

4-cyanobenzoic Acid

4-cyanobenzoyl chlorIde

toluene-4-sulfonamide