2,5-Dichlorobenzylamine

Base Information

• Chemical Name: 2,5-Dichlorobenzylamine
• CAS No.: 10541-69-2
• Molecular Formula: C7H7Cl2N
• Molecular Weight: 176.045
• Hs Code.: 2921499090
• Mol file: 10541-69-2.mol

Synonyms:Benzylamine,2,5-dichloro- (6CI,7CI,8CI);1-(2,5-Dichlorophenyl)methanamine;[(2,5-Dichlorophenyl)methyl]amine;

Chemical Property of 2,5-Dichlorobenzylamine

Chemical Property:

• Vapor Pressure: 0.0207mmHg at 25°C
• Melting Point: 191-192 °C
• Refractive Index: n20/D 1.579(lit.)
• Boiling Point: 248.761 °C at 760 mmHg
• PKA: 8.23±0.10(Predicted)
• Flash Point: 104.247 °C
• PSA: 26.02000
• Density: 1.32 g/cm³
• LogP: 3.15240
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive
• Solubility.: Not miscible or difficult to mix.

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,5-Dichlorobenzylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T,C,Xi
• Hazard Codes: T,C,Xi
• Statements: 25-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,5-Dichlorobenzylamine is a dichlorinated benzylamine with inhibitory effect on phenylethanolamine N-methyl transferase. 2,5-Dichlorobenzylamine is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Technology Process of 2,5-Dichlorobenzylamine

There total 6 articles about 2,5-Dichlorobenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichlorobenzaldoxime (80959-18-8) → 2,5-dichloro-benzylamine (10541-69-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jm00375a005

Reference yield:

2-(2,5-dichlorobenzyl)isoindoline-1,3-dione (793695-86-0) → 2,5-dichloro-benzylamine (10541-69-2)

Guidance literature:

With hydrazine; In ethanol; for 24h; Heating;

DOI:10.1021/jm049580r

Reference yield:

2,5-dichlorobenzylbromide (85482-13-9) → 2,5-dichloro-benzylamine (10541-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / 3 h / 80 °C

2: hydrazine / ethanol / 24 h / Heating

With hydrazine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm049580r

upstream raw materials:

2,5-dichloro-benzaldehyde

ammonium formate

2,4-dichlorobenzaldoxime

2,5-dichlorotoluene

Downstream raw materials:

8-(2,5-dichlorobenzyl)-1,3-dimethyl-6,7,8,9-tetrahydropyrazino[2,1-f]purine-2,4(1H,3H)-dione

C₁₉H₂₂Cl₂N₄O₂

N-(2,5-dichlorobenzyl)-2-chloro-5-nitropyrimidin-4-amine

C₃₄H₄₅Cl₃N₄O₇S

Refernces

• 1、 Meindl,Von Angerer,Schonenberger,Ruckdeschel. "Benzylamines: Synthesis and evaluation of antimycobacterial properties". . p. 1111 - 1118. Retrieved 2007/10/02.