5-Azaspiro[2.5]oct-7-ene-7-carboxamide, 8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[(2 ,3-dichlorophenyl)methyl]-

Base Information

Chemical Name:5-Azaspiro[2.5]oct-7-ene-7-carboxamide, 8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[(2 ,3-dichlorophenyl)methyl]-
CAS No.:851314-27-7
Molecular Formula:C₃₃H₃₁Cl₃F₂N₂O₂
Molecular Weight:631.977
Hs Code.:

5-Azaspiro[2.5]oct-7-ene-7-carboxamide,
8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[(2
,3-dichlorophenyl)methyl]-

Synonyms:

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Chemical Property of 5-Azaspiro[2.5]oct-7-ene-7-carboxamide, 8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[(2 ,3-dichlorophenyl)methyl]-

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Technology Process of 5-Azaspiro[2.5]oct-7-ene-7-carboxamide, 8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[(2 ,3-dichlorophenyl)methyl]-

There total 8 articles about 5-Azaspiro[2.5]oct-7-ene-7-carboxamide, 8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[(2 ,3-dichlorophenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202647-31-1
C₃₈H₃₉Cl₃F₂N₂O₄

: 851314-27-7
8-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5-aza-spiro[2.5]oct-7-ene-7-carboxylic acid cyclopropyl-(2,3-dichlorobenzyl)amide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2009.09.104

Reference yield:

: 143306-64-3
tert-butyl 8-oxo-5-azaspiro[2.5]octane-5-carboxylate

: 851314-27-7
8-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5-aza-spiro[2.5]oct-7-ene-7-carboxylic acid cyclopropyl-(2,3-dichlorobenzyl)amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran

1.2: -78 °C

2.1: sodium hydride / tetrahydrofuran

3.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide; isopropyl alcohol / 1 h / 80 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 72 h / 60 °C

4.2: 20 °C

5.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0 - 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; water; sodium hydride; sodium carbonate; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 3.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2009.09.104

Reference yield:

: 851314-35-7
8-oxo-5-aza-spiro[2.5]octane-5,7-dicarboxylic acid 5-tert-butyl ester 7-methyl ester

: 851314-27-7
8-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5-aza-spiro[2.5]oct-7-ene-7-carboxylic acid cyclopropyl-(2,3-dichlorobenzyl)amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide; isopropyl alcohol / 1 h / 80 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 72 h / 60 °C

3.2: 20 °C

4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0 - 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; water; sodium hydride; sodium carbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 2.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2009.09.104