5-Azaspiro[2.5]oct-7-ene-5,7-dicarboxylic acid, 8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-, 5-(1,1-dimethylethyl) 7-methyl ester

Base Information

Chemical Name:5-Azaspiro[2.5]oct-7-ene-5,7-dicarboxylic acid, 8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-, 5-(1,1-dimethylethyl) 7-methyl ester
CAS No.:851314-48-2
Molecular Formula:C29H32ClF2NO5
Molecular Weight:548.027
Hs Code.:

5-Azaspiro[2.5]oct-7-ene-5,7-dicarboxylic acid,
8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-,
5-(1,1-dimethylethyl) 7-methyl ester

Synonyms:

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Chemical Property of 5-Azaspiro[2.5]oct-7-ene-5,7-dicarboxylic acid, 8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-, 5-(1,1-dimethylethyl) 7-methyl ester

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Technology Process of 5-Azaspiro[2.5]oct-7-ene-5,7-dicarboxylic acid, 8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-, 5-(1,1-dimethylethyl) 7-methyl ester

There total 7 articles about 5-Azaspiro[2.5]oct-7-ene-5,7-dicarboxylic acid, 8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-, 5-(1,1-dimethylethyl) 7-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 851314-38-0
8-trifluoromethanesulfonyloxy-5-aza-spiro[2.5]oct-7-ene-5,7-dicarboxylic acid 5-tert-butyl ester 7-methyl ester

: 1202647-16-2
C₂₁H₂₄BClF₂O₃

: 851314-48-2
8-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5-aza-spiro[2.5]oct-7-ene-5,7-dicarboxylic acid 5-tert-butyl ester 7-methyl ester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; N,N-dimethyl-formamide; isopropyl alcohol; at 80 ℃; for 1h;
DOI:10.1016/j.bmcl.2009.09.104

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 851314-48-2
8-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5-aza-spiro[2.5]oct-7-ene-5,7-dicarboxylic acid 5-tert-butyl ester 7-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate; tert-butyl alcohol

2.1: lithium diisopropyl amide / tetrahydrofuran

2.2: -78 °C

3.1: sodium hydride / tetrahydrofuran

4.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide; isopropyl alcohol / 1 h / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium tert-butylate; sodium hydride; sodium carbonate; tert-butyl alcohol; lithium diisopropyl amide; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol; 4.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2009.09.104

Reference yield:

: 143306-64-3
tert-butyl 8-oxo-5-azaspiro[2.5]octane-5-carboxylate

: 851314-48-2
8-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5-aza-spiro[2.5]oct-7-ene-5,7-dicarboxylic acid 5-tert-butyl ester 7-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran

1.2: -78 °C

2.1: sodium hydride / tetrahydrofuran

3.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide; isopropyl alcohol / 1 h / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium hydride; sodium carbonate; lithium diisopropyl amide; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol; 3.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2009.09.104