Technology Process of 1(2H)-Pyridinecarboxylic acid,
4-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-5-[[cyclopropyl[(2,3-
dichlorophenyl)methyl]amino]carbonyl]-3,3-difluoro-3,6-dihydro-,
1,1-dimethylethyl ester
There total 11 articles about 1(2H)-Pyridinecarboxylic acid,
4-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-5-[[cyclopropyl[(2,3-
dichlorophenyl)methyl]amino]carbonyl]-3,3-difluoro-3,6-dihydro-,
1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
dmap; benzotriazol-1-ol;
In
dichloromethane;
for 72h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 2 h / Reflux
2.1: water; sodium hydroxide / ethanol / 5 h
2.2: 72 h / 20 °C
With
tributylphosphine; water; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine;
In
ethanol; toluene;
1.1: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2009.09.104
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium on activated charcoal; hydrogen; acetic acid / ethanol / 4 h / 20 °C
2.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 2 h / Reflux
3.1: water; sodium hydroxide / ethanol / 5 h
3.2: 72 h / 20 °C
With
tributylphosphine; palladium on activated charcoal; water; hydrogen; acetic acid; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine;
In
ethanol; toluene;
2.1: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2009.09.104
