4-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5,5-difluoro-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester

Base Information

Chemical Name:4-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5,5-difluoro-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester
CAS No.:851314-53-9
Molecular Formula:C₂₆H₂₆ClF₄NO₅
Molecular Weight:543.943
Hs Code.:

Synonyms:4-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5,5-difluoro-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester

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Chemical Property of 4-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5,5-difluoro-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester

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Technology Process of 4-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5,5-difluoro-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester

There total 7 articles about 4-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5,5-difluoro-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 851314-50-6
4-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5,5-difluoro-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

: 851314-53-9
4-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5,5-difluoro-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: 4-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5,5-difluoro-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester; With sodium hydroxide; water; at 20 ℃; for 4h;

With hydrogenchloride; at 20 ℃;

Reference yield:

: 851314-55-1
ethyl N-[3-(ethyloxy)-2,2-difluoro-3-oxopropyl]-N-(phenylmethyl)-beta-alaninate

: 851314-53-9
4-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5,5-difluoro-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / -78 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 72 h / 45 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 18 h / 45 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 24 h

5.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 1.5 h / 20 - 65 °C

6.1: sodium hydroxide; water / 4 h / 20 °C

6.2: 20 °C

With sodium hydroxide; n-butyllithium; tributylphosphine; water; hydrogen; sodium hydride; diisopropylamine; 1,1'-azodicarbonyl-dipiperidine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; toluene; 1.1: Dieckmann Reaction / 5.1: Mitsunobu reaction;

Reference yield:

: 851314-44-8
1-benzyl-4-{4-[3-(tert-butyldimethylsilanyloxy)propyl]phenyl}-5,5-difluoro-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester

: 851314-53-9
4-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5,5-difluoro-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 24 h

2.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 1.5 h / 20 - 65 °C

3.1: sodium hydroxide; water / 4 h / 20 °C

3.2: 20 °C

With sodium hydroxide; tributylphosphine; water; hydrogen; 1,1'-azodicarbonyl-dipiperidine; palladium 10% on activated carbon; In ethanol; toluene; 2.1: Mitsunobu reaction;