1H-Pyrrole-2-methanol, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,5-dihydro-4-(2-methyl- 1,3-dioxolan-2-yl)-1-[(4-methylphenyl)sulfonyl]-

Base Information

Chemical Name:1H-Pyrrole-2-methanol, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,5-dihydro-4-(2-methyl- 1,3-dioxolan-2-yl)-1-[(4-methylphenyl)sulfonyl]-
CAS No.:851315-57-6
Molecular Formula:C24H39NO6SSi
Molecular Weight:497.728
Hs Code.:

1H-Pyrrole-2-methanol,
3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,5-dihydro-4-(2-methyl-
1,3-dioxolan-2-yl)-1-[(4-methylphenyl)sulfonyl]-

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Chemical Property of 1H-Pyrrole-2-methanol, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,5-dihydro-4-(2-methyl- 1,3-dioxolan-2-yl)-1-[(4-methylphenyl)sulfonyl]-

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Technology Process of 1H-Pyrrole-2-methanol, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,5-dihydro-4-(2-methyl- 1,3-dioxolan-2-yl)-1-[(4-methylphenyl)sulfonyl]-

There total 5 articles about 1H-Pyrrole-2-methanol, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,5-dihydro-4-(2-methyl- 1,3-dioxolan-2-yl)-1-[(4-methylphenyl)sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 851315-56-5
2-benzyloxymethyl-3-[2-(tertbutyldimethylsialnoxy)-ethyl]-4-(2-methyl-[1,3]-dioxolan-2-yl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole

: 851315-57-6
[3-[2-(tert-butyldimethylsilanoxy)ethyl]-4-(2-methyl-[1,3]-dioxolan-2-yl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-2-yl]methanol

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; for 1.5h;
DOI:10.1021/ja043097o

Reference yield:

: 851315-52-1
1-[5-benzyloxymethyl-1-(toluene-4-sulfonyl)vinyl-2,5-dihydro-1H-pyrrol-3-yl]ethanone

: 851315-57-6
[3-[2-(tert-butyldimethylsilanoxy)ethyl]-4-(2-methyl-[1,3]-dioxolan-2-yl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-2-yl]methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 80 percent / pTSA*H₂O / 8.5 h / Heating

2.1: Cy₂BH / tetrahydrofuran / 20 h / 20 °C

2.2: 82 percent / aq. NaOH; H₂O₂ / tetrahydrofuran / 5 h / 0 - 20 °C

3.1: 91 percent / imidazole / dimethylformamide / 15 h

4.1: 100 percent / H₂ / Pd(OH)2/C / methanol / 1.5 h

With 1H-imidazole; bis(cyclohexanyl)borane; hydrogen; toluene-4-sulfonic acid; palladium dihydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/ja043097o

Reference yield:

: 851315-50-9
N-(1-benzyloxymethyl-4-hydroxybut-2-ynyl)-N-but-2-ynyl-4-methylbenzenesulfonamide

: 851315-57-6
[3-[2-(tert-butyldimethylsilanoxy)ethyl]-4-(2-methyl-[1,3]-dioxolan-2-yl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-2-yl]methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 80 percent / malonic acid; CpRu[(CH₃CN)3]PF₆ / H₂O; acetone / 1 h / 45 °C

2.1: 80 percent / pTSA*H₂O / 8.5 h / Heating

3.1: Cy₂BH / tetrahydrofuran / 20 h / 20 °C

3.2: 82 percent / aq. NaOH; H₂O₂ / tetrahydrofuran / 5 h / 0 - 20 °C

4.1: 91 percent / imidazole / dimethylformamide / 15 h

5.1: 100 percent / H₂ / Pd(OH)2/C / methanol / 1.5 h

With 1H-imidazole; cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; malonic acid; bis(cyclohexanyl)borane; hydrogen; toluene-4-sulfonic acid; palladium dihydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja043097o