1H-Pyrrole, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,5-dihydro-4-(2-methyl- 1,3-dioxolan-2-yl)-1-[(4-methylphenyl)sulfonyl]-2-[(phenylmethoxy)methyl] -

Base Information

Chemical Name:1H-Pyrrole, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,5-dihydro-4-(2-methyl- 1,3-dioxolan-2-yl)-1-[(4-methylphenyl)sulfonyl]-2-[(phenylmethoxy)methyl] -
CAS No.:851315-56-5
Molecular Formula:C31H45NO6SSi
Molecular Weight:587.853
Hs Code.:

1H-Pyrrole,
3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,5-dihydro-4-(2-methyl-
1,3-dioxolan-2-yl)-1-[(4-methylphenyl)sulfonyl]-2-[(phenylmethoxy)methyl]
-

Synonyms:

Suppliers and Price of 1H-Pyrrole, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,5-dihydro-4-(2-methyl- 1,3-dioxolan-2-yl)-1-[(4-methylphenyl)sulfonyl]-2-[(phenylmethoxy)methyl] -

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1H-Pyrrole, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,5-dihydro-4-(2-methyl- 1,3-dioxolan-2-yl)-1-[(4-methylphenyl)sulfonyl]-2-[(phenylmethoxy)methyl] -

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1H-Pyrrole, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,5-dihydro-4-(2-methyl- 1,3-dioxolan-2-yl)-1-[(4-methylphenyl)sulfonyl]-2-[(phenylmethoxy)methyl] -

There total 4 articles about 1H-Pyrrole, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,5-dihydro-4-(2-methyl- 1,3-dioxolan-2-yl)-1-[(4-methylphenyl)sulfonyl]-2-[(phenylmethoxy)methyl] - which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 851315-55-4
2-[2-benzyloxymethyl-4-(2-methyl-[1,3]-dioxolan-2-yl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-ethanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 851315-56-5
2-benzyloxymethyl-3-[2-(tertbutyldimethylsialnoxy)-ethyl]-4-(2-methyl-[1,3]-dioxolan-2-yl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 15h;
DOI:10.1021/ja043097o

Reference yield:

: 851315-50-9
N-(1-benzyloxymethyl-4-hydroxybut-2-ynyl)-N-but-2-ynyl-4-methylbenzenesulfonamide

: 851315-56-5
2-benzyloxymethyl-3-[2-(tertbutyldimethylsialnoxy)-ethyl]-4-(2-methyl-[1,3]-dioxolan-2-yl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 80 percent / malonic acid; CpRu[(CH₃CN)3]PF₆ / H₂O; acetone / 1 h / 45 °C

2.1: 80 percent / pTSA*H₂O / 8.5 h / Heating

3.1: Cy₂BH / tetrahydrofuran / 20 h / 20 °C

3.2: 82 percent / aq. NaOH; H₂O₂ / tetrahydrofuran / 5 h / 0 - 20 °C

4.1: 91 percent / imidazole / dimethylformamide / 15 h

With 1H-imidazole; cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; malonic acid; bis(cyclohexanyl)borane; toluene-4-sulfonic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja043097o

Reference yield:

: 851315-52-1
1-[5-benzyloxymethyl-1-(toluene-4-sulfonyl)vinyl-2,5-dihydro-1H-pyrrol-3-yl]ethanone

: 851315-56-5
2-benzyloxymethyl-3-[2-(tertbutyldimethylsialnoxy)-ethyl]-4-(2-methyl-[1,3]-dioxolan-2-yl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / pTSA*H₂O / 8.5 h / Heating

2.1: Cy₂BH / tetrahydrofuran / 20 h / 20 °C

2.2: 82 percent / aq. NaOH; H₂O₂ / tetrahydrofuran / 5 h / 0 - 20 °C

3.1: 91 percent / imidazole / dimethylformamide / 15 h

With 1H-imidazole; bis(cyclohexanyl)borane; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja043097o