Silane, trimethyl[[2-(4-methylphenyl)-1-cyclohexen-1-yl]oxy]-

Base Information

• Chemical Name: Silane, trimethyl[[2-(4-methylphenyl)-1-cyclohexen-1-yl]oxy]-
• CAS No.: 851332-01-9
• Molecular Formula: C16H24OSi
• Molecular Weight: 260.451
• Mol file: 851332-01-9.mol

Synonyms:

Chemical Property of Silane, trimethyl[[2-(4-methylphenyl)-1-cyclohexen-1-yl]oxy]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Silane, trimethyl[[2-(4-methylphenyl)-1-cyclohexen-1-yl]oxy]-

There total 5 articles about Silane, trimethyl[[2-(4-methylphenyl)-1-cyclohexen-1-yl]oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

chloro-trimethyl-silane (75-77-4) + 2-(4-methylphenyl)cyclohexanone (52776-14-4) → 2-(4-methylphenyl)-1-(trimethylsiloxy)cyclohex-1-ene (851332-01-9)

Guidance literature:

2-(4-methylphenyl)cyclohexanone; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

chloro-trimethyl-silane; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ja8041542

Reference yield:

1-(Trimethylsilyloxy)cyclohexene (6651-36-1) → 2-(4-methylphenyl)-1-(trimethylsiloxy)cyclohex-1-ene (851332-01-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tributyltin fluoride; triethylamine; tri tert-butylphosphoniumtetrafluoroborate / benzene / 24 h / 80 °C / Inert atmosphere

2: pyridine; sodium iodide / hexane; acetonitrile / 20 h / 20 °C

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tributyltin fluoride; triethylamine; sodium iodide; tri tert-butylphosphoniumtetrafluoroborate; In hexane; acetonitrile; benzene;

DOI:10.1021/ol201608a

Reference yield:

4-tolyl iodide (624-31-7) → 2-(4-methylphenyl)-1-(trimethylsiloxy)cyclohex-1-ene (851332-01-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tributyltin fluoride; triethylamine; tri tert-butylphosphoniumtetrafluoroborate / benzene / 24 h / 80 °C / Inert atmosphere

2: pyridine; sodium iodide / hexane; acetonitrile / 20 h / 20 °C

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tributyltin fluoride; triethylamine; sodium iodide; tri tert-butylphosphoniumtetrafluoroborate; In hexane; acetonitrile; benzene;

DOI:10.1021/ol201608a

upstream raw materials:

chloro-trimethyl-silane

2-(4-methylphenyl)cyclohexanone

1-(Trimethylsilyloxy)cyclohexene

4-tolyl iodide

Downstream raw materials:

(R)-(-)-2-(4-methylphenyl)cyclohexanone

(S)-(-)-2-(4-methylphenyl)cyclohexanone