Cyclohept[b]indole, 5,5a,6,7,8,9,10,10a-octahydro-

Base Information

• Chemical Name: Cyclohept[b]indole, 5,5a,6,7,8,9,10,10a-octahydro-
• CAS No.: 855405-55-9
• Molecular Formula: C₁₃H₁₇N
• Molecular Weight: 187.285
• Mol file: 855405-55-9.mol

Synonyms:Cyclohept[b]indole;CYCLOHEPT[B]INDOLE, 5,5A,6,7,8,9,10,10A-OCTAHYDRO-;5,5A,6,7,8,9,10,10A-OCTAHYDRO-CYCLOHEPT[B]INDOLE;

Chemical Property of Cyclohept[b]indole, 5,5a,6,7,8,9,10,10a-octahydro-

Chemical Property:

• PSA: 12.03000
• LogP: 3.66640

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohept[b]indole, 5,5a,6,7,8,9,10,10a-octahydro-

There total 11 articles about Cyclohept[b]indole, 5,5a,6,7,8,9,10,10a-octahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5,6,7,8,9,10-hexahydrocyclohept[b]indole (2047-89-4) → 5,5a,6,7,8,9,10,10a-octahydrocyclohept[b]indole (855405-55-9)

Guidance literature:

With palladium(II) trifluoroacetate; 2,2,2-trifluoroethanol; (R)-10-camphorsulfonic acid; hydrogen; (R)-(+)-2,2'-bis(diphenylphosphanyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl; In dichloromethane; at 20 ℃; for 24h; under 36201.3 Torr; optical yield given as %ee; enantioselective reaction; Autoclave;

DOI:10.1021/ja103668q

Reference yield:

5,6,7,8,9,10-hexahydrocyclohept[b]indole (2047-89-4) → 5,5a,6,7,8,9,10,10a-octahydrocyclohepta[b]indole (855405-55-9)

Guidance literature:

With palladium(II) trifluoroacetate; 5,5'-decamethylenedioxy-2,2'-bis(diphenylphosphino)biphenyl; (1S)-10-camphorsulfonic acid; hydrogen; In dichloromethane; at 35 ℃; for 24h; under 45004.5 Torr; enantioselective reaction; Autoclave;

DOI:10.1016/j.tet.2013.06.016

Reference yield:

5,6,7,8,9,10-hexahydrocyclohept[b]indole (2047-89-4) → 5,5a,6,7,8,9,10,10a-octahydrocyclohepta[b]indole (855405-55-9)

Guidance literature:

With sodium cyanoborohydride; In acetic acid; at 20 ℃; for 12h;

DOI:10.1021/ja0657859

upstream raw materials:

5,6,7,8,9,10-hexahydrocyclohept[b]indole

4-tert-butyl-2-phenyloxazol-5-yl acetate

cis-5,5a,6,7,8,9,10,10a-octahydrocyclohept[b]indole

phenylhydrazine