1-(4-Fluorophenyl)-3-azabicyclo[3.1.0]hexane

Base Information

Chemical Name:1-(4-Fluorophenyl)-3-azabicyclo[3.1.0]hexane
CAS No.:86215-41-0
Molecular Formula:C11H12FN
Molecular Weight:177.221
Hs Code.:
DSSTox Substance ID:DTXSID30437986
ChEMBL ID:CHEMBL1191622

Synonyms:1-(4-fluorophenyl)-3-azabicyclo[3.1.0]hexane;86215-41-0;SCHEMBL4714734;CHEMBL1191622;DTXSID30437986;MB69063

Suppliers and Price of 1-(4-Fluorophenyl)-3-azabicyclo[3.1.0]hexane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-Fluorophenyl)-3-azabicyclo[3.1.0]hexane

Chemical Property:

PSA：12.03000
LogP:2.01540
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:177.095377549
Heavy Atom Count:13
Complexity:210

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C2C1(CNC2)C3=CC=C(C=C3)F

Technology Process of 1-(4-Fluorophenyl)-3-azabicyclo[3.1.0]hexane

There total 5 articles about 1-(4-Fluorophenyl)-3-azabicyclo[3.1.0]hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 66504-49-2
1-(p-Fluorphenyl)-1,2-cyclopropan-dicarboximid

: 86215-41-0
(+/-)-1-(4-fluorophenyl)-3-azabicyclo[3.1.0]hexane

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In benzene; for 2h; Heating;
DOI:10.1021/jm00137a002

Reference yield:

: 34837-84-8
4-fluorobenzeneacetic acid methyl ester

: 86215-41-0
(+/-)-1-(4-fluorophenyl)-3-azabicyclo[3.1.0]hexane

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / NBS, 48percent aq. HBr / CCl₄ / Heating

2: 57 percent / NaOMe / diethyl ether / 24 h / Ambient temperature

3: 45 percent / KOH / ethanol; H₂O / 6 h / Heating

4: 58 percent / urea / xylene / Heating

5: 81 percent / sodium bis(2-methoxyethoxy)aluminum hydride / benzene / 2 h / Heating

With potassium hydroxide; N-Bromosuccinimide; hydrogen bromide; sodium methylate; sodium bis(2-methoxyethoxy)aluminium dihydride; urea; In tetrachloromethane; diethyl ether; ethanol; water; xylene; benzene;
DOI:10.1021/jm00137a002

Reference yield:

: 77053-79-3
(1R,2S)-1-(4-Fluoro-phenyl)-cyclopropane-1,2-dicarboxylic acid

: 86215-41-0
(+/-)-1-(4-fluorophenyl)-3-azabicyclo[3.1.0]hexane

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / urea / xylene / Heating

2: 81 percent / sodium bis(2-methoxyethoxy)aluminum hydride / benzene / 2 h / Heating

With sodium bis(2-methoxyethoxy)aluminium dihydride; urea; In xylene; benzene;
DOI:10.1021/jm00137a002