(1R,2S)-1-(4-Fluoro-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester

Base Information

Chemical Name:(1R,2S)-1-(4-Fluoro-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester
CAS No.:77053-69-1
Molecular Formula:C₁₃H₁₃FO₄
Molecular Weight:252.242
Hs Code.:

Synonyms:(1R,2S)-1-(4-Fluoro-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester

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Chemical Property of (1R,2S)-1-(4-Fluoro-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester

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Technology Process of (1R,2S)-1-(4-Fluoro-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester

There total 2 articles about (1R,2S)-1-(4-Fluoro-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 71783-54-5
methyl 2-bromo-2-(4-fluorophenyl)acetate

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 77053-69-1
(1R,2S)-1-(4-Fluoro-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester

Guidance literature:: With sodium methylate; In diethyl ether; for 24h; Ambient temperature;
DOI:10.1021/jm00137a002

Reference yield:

: 34837-84-8
4-fluorobenzeneacetic acid methyl ester

: 77053-69-1
(1R,2S)-1-(4-Fluoro-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / NBS, 48percent aq. HBr / CCl₄ / Heating

2: 57 percent / NaOMe / diethyl ether / 24 h / Ambient temperature

With N-Bromosuccinimide; hydrogen bromide; sodium methylate; In tetrachloromethane; diethyl ether;
DOI:10.1021/jm00137a002