Cyclopentanecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 1,1-dimethylethyl ester, (1R,2R,4R)-

Base Information

Chemical Name:Cyclopentanecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 1,1-dimethylethyl ester, (1R,2R,4R)-
CAS No.:862174-63-8
Molecular Formula:C35H40N2O7
Molecular Weight:600.712
Hs Code.:

Cyclopentanecarboxylic acid,
2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4-
[(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 1,1-dimethylethyl ester,
(1R,2R,4R)-

Synonyms:

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Chemical Property of Cyclopentanecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 1,1-dimethylethyl ester, (1R,2R,4R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclopentanecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 1,1-dimethylethyl ester, (1R,2R,4R)-

There total 8 articles about Cyclopentanecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 1,1-dimethylethyl ester, (1R,2R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 862174-62-7
(1R,2R,4S)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-hydroxy-cyclopenteanecarboxylic acid tert-butyl ester

: 20430-72-2,189816-04-4
7-methoxy-2-phenylquinolin-4-ol

: 862174-63-8
(1R,2R,4S)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopenteanecarboxylic acid tert-butyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 48h;
DOI:10.1016/j.bmc.2006.04.008

Reference yield:

: 259214-54-5,259214-56-7
ethyl (1R,2S)-1-amino-2-vinylcyclopropanecarboxylate hydrochloride

: 862174-63-8
(1R,2R,4S)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopenteanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 mg / diisopropylethylamine; O-(7-azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium PF₆ / dimethylformamide / 2.5 h / 0 - 20 °C

2: 68 percent / triphenylphosphine; diisopropyl diazodicarboxylate / tetrahydrofuran / 48 h / 20 °C

With di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.04.008

Reference yield:

: 862174-60-5
(1R,4R,5R)-3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxylic acid

: 862174-63-8
(1R,2R,4S)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopenteanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 52 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 0 - 20 °C

2: lithium hydroxide / dioxane; H₂O / 0.75 h / 0 °C

3: 86 mg / diisopropylethylamine; O-(7-azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium PF₆ / dimethylformamide / 2.5 h / 0 - 20 °C

4: 68 percent / triphenylphosphine; diisopropyl diazodicarboxylate / tetrahydrofuran / 48 h / 20 °C

With dmap; lithium hydroxide; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 4: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.04.008