Octanamide, 2-ethyl-N-phenyl-N-(phenylmethyl)-, (2R)-

Base Information

• Chemical Name: Octanamide, 2-ethyl-N-phenyl-N-(phenylmethyl)-, (2R)-
• CAS No.: 866594-20-9
• Molecular Formula: C23H31NO
• Molecular Weight: 337.505
• Mol file: 866594-20-9.mol

Synonyms:

Chemical Property of Octanamide, 2-ethyl-N-phenyl-N-(phenylmethyl)-, (2R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Octanamide, 2-ethyl-N-phenyl-N-(phenylmethyl)-, (2R)-

There total 4 articles about Octanamide, 2-ethyl-N-phenyl-N-(phenylmethyl)-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-bromo-N-phenyl-N-(phenylmethyl)-butanamide (851073-30-8) + (1-hexyl)zinc(II) bromide (124397-96-2) → (R)-(+)-N-benzyl-N-phenyl-2-ethyloctanamide (866594-20-9)

Guidance literature:

With 2,6-bis((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)pyridine; In various solvent(s); at 0 ℃; for 12h;

DOI:10.1021/ja0506509

Reference yield: 90.0%

2-bromo-N-phenyl-N-(phenylmethyl)-butanamide (851073-30-8) + (1-hexyl)zinc(II) bromide (124397-96-2) → (R)-(+)-N-benzyl-N-phenyl-2-ethyloctanamide (866594-20-9) + (S)-(-)-N-benzyl-N-phenyl-2-ethyloctanamide

Guidance literature:

(1,2-dimethoxyethane)dichloronickel(II); 2,6-bis((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)pyridine; In tetrahydrofuran; at 0 ℃; for 12h; Title compound not separated from byproducts;

DOI:10.1021/ja0506509

Reference yield: 89.0%

trans-3-Hexene (13269-52-8) + 2-bromo-N-phenyl-N-(phenylmethyl)-butanamide (851073-30-8) → (R)-(+)-N-benzyl-N-phenyl-2-ethyloctanamide (866594-20-9) + (S)-(-)-N-benzyl-N-phenyl-2-ethyloctanamide

Guidance literature:

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium fluoride; nickel(II) iodide monohydrate; diethoxymethylane; (S)-4-(4-fluorophenyl)-2-(6-methylpyridin-2-yl)-5,5-diphenyl-4,5-dihydrooxazole; In 1,2-dichloro-ethane; at -25 ℃; for 24h; enantioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201813222

upstream raw materials:

2-bromo-N-phenyl-N-(phenylmethyl)-butanamide

(1-hexyl)zinc(II) bromide

N-Benzylaniline

trans-3-Hexene