1-[3,5-Bis(hydroxymethyl)phenyl]pyrimidine-2,4-dione

Base Information

Chemical Name:1-[3,5-Bis(hydroxymethyl)phenyl]pyrimidine-2,4-dione
CAS No.:867259-20-9
Molecular Formula:C12H12N2O4
Molecular Weight:248.238
Hs Code.:
DSSTox Substance ID:DTXSID70467868
Nikkaji Number:J2.064.481H

Synonyms:867259-20-9;CTK2I3202;DTXSID70467868

Suppliers and Price of 1-[3,5-Bis(hydroxymethyl)phenyl]pyrimidine-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[3,5-Bis(hydroxymethyl)phenyl]pyrimidine-2,4-dione

Chemical Property:

XLogP3:-1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:248.07970687
Heavy Atom Count:18
Complexity:357

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN(C(=O)NC1=O)C2=CC(=CC(=C2)CO)CO

Technology Process of 1-[3,5-Bis(hydroxymethyl)phenyl]pyrimidine-2,4-dione

There total 4 articles about 1-[3,5-Bis(hydroxymethyl)phenyl]pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1180533-51-0
1-[3,5-bis(tert-butyldimethylsilyloxymethyl)phenyl]cytosine

: 867259-20-9
1-[3,5-bis(hydroxymethyl)phenyl]uracil

Guidance literature:: 1-[3,5-bis(tert-butyldimethylsilyloxymethyl)phenyl]cytosine; With hydrogenchloride; In water; at 20 ℃; for 1h;

With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 3h;

With hydrogenchloride; water; at 110 ℃; for 72h;
DOI:10.1039/b901631g

Reference yield: 45.0%

: N-[3,5-bis(tert-butyldimethylsilanyloxymethyl)phenylcarbamoyl]-3-methoxy-2-propenamide

: 867259-20-9
1-[3,5-bis(hydroxymethyl)phenyl]uracil

Guidance literature:: With sodium hydroxide; In ethanol; at 60 ℃; for 1h;
DOI:10.1021/jo050635m

Reference yield:

: 867259-24-3
3,5-bis-(t-butyldimethylsilyloxymethyl)-1-aminobenzene

: 867259-20-9
1-[3,5-bis(hydroxymethyl)phenyl]uracil

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / benzene; dimethylformamide / -20 - 20 °C

2: 45 percent / NaOH / ethanol / 1 h / 60 °C

With sodium hydroxide; In ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo050635m