Technology Process of 1-[3,5-bis(4,4'-dimethoxytrityloxymethyl)phenyl]cytosine
There total 6 articles about 1-[3,5-bis(4,4'-dimethoxytrityloxymethyl)phenyl]cytosine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-[3,5-bis(4,4'-dimethoxytrityloxymethyl)phenyl]uracil;
With
dmap; 2,4,6-triisopropylphenylsulfonyl chloride; triethylamine;
In
acetonitrile;
at 20 ℃;
for 1h;
With
ammonium hydroxide;
In
acetonitrile;
at 20 ℃;
for 19h;
DOI:10.1021/jo050635m
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 66 percent / 4-dimethylaminopyridine; pyridine / 18 h / 20 °C
2.1: 2,4,6-triisopropylbenzenesulfonyl chloride; triethylamine; 4-dimethylaminopyridine / acetonitrile / 1 h / 20 °C
2.2: 97 percent / NH4OH / acetonitrile / 19 h / 20 °C
With
pyridine; dmap; 2,4,6-triisopropylphenylsulfonyl chloride; triethylamine;
In
acetonitrile;
DOI:10.1021/jo050635m
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 86 percent / benzene; dimethylformamide / -20 - 20 °C
2.1: 45 percent / NaOH / ethanol / 1 h / 60 °C
3.1: 66 percent / 4-dimethylaminopyridine; pyridine / 18 h / 20 °C
4.1: 2,4,6-triisopropylbenzenesulfonyl chloride; triethylamine; 4-dimethylaminopyridine / acetonitrile / 1 h / 20 °C
4.2: 97 percent / NH4OH / acetonitrile / 19 h / 20 °C
With
pyridine; dmap; sodium hydroxide; 2,4,6-triisopropylphenylsulfonyl chloride; triethylamine;
In
ethanol; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo050635m
![1-[3,5-bis(4,4'-dimethoxytrityloxymethyl)phenyl]uracil](/Databaselist/images/loading.webp)
