2(1H)-Quinolinone, 3,4-dihydro-6-(1-piperazinyl)-, monohydrobromide

Base Information

• Chemical Name: 2(1H)-Quinolinone, 3,4-dihydro-6-(1-piperazinyl)-, monohydrobromide
• CAS No.: 86813-31-2
• Molecular Formula: C13H17N3O.BrH
• Molecular Weight: 312.209
• Mol file: 86813-31-2.mol

Synonyms:

Chemical Property of 2(1H)-Quinolinone, 3,4-dihydro-6-(1-piperazinyl)-, monohydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(1H)-Quinolinone, 3,4-dihydro-6-(1-piperazinyl)-, monohydrobromide

There total 1 articles about 2(1H)-Quinolinone, 3,4-dihydro-6-(1-piperazinyl)-, monohydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-amino-3,4-dihydro-1H-quinolin-2-one (22246-13-5) + bis(2-bromoethyl)amine hydrobromide (43204-63-3) → 6-(1-piperazinyl)-3,4-dihydrocarbostyril hydrobromide (86813-31-2)

Guidance literature:

With sodium carbonate; Yield given. Multistep reaction; 1.) EtOH, reflux, 8 h; 2.) reflux, 8 h;

DOI:10.1248/cpb.32.2100

Reference yield: 70.0%

6-(1-piperazinyl)-3,4-dihydrocarbostyril hydrobromide (86813-31-2) + 3,4-dimethoxybenzoic acid chloride (3535-37-3) → vesnarinone (81840-15-5)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1248/cpb.32.2100

Reference yield: 67.0%

benzoyl chloride (98-88-4) + 6-(1-piperazinyl)-3,4-dihydrocarbostyril hydrobromide (86813-31-2) → 6-(4-Benzoyl-1-piperazinyl)-3,4-dihydrocarbostyril (81840-19-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1248/cpb.32.2100

upstream raw materials:

6-amino-3,4-dihydro-1H-quinolin-2-one

bis(2-bromoethyl)amine hydrobromide

Downstream raw materials:

6-[4-((E)-3-p-Tolyl-acryloyl)-piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one

6-(4-Benzoyl-1-piperazinyl)-3,4-dihydrocarbostyril

6-[4-(4-chlorobenzyl)-1-piperazinyl]-3,4-dihydrocarbostyril

6-[4-(4-Chlorobenzoyl)-1-piperazinyl]-3,4,-dihydrocarbostyril

Refernces

• 1、 -. "Piperazinylcarbostyril compounds". . . Retrieved 2008/06/13.