Tasuldine

Base Information

• Chemical Name: Tasuldine
• CAS No.: 88579-39-9
• Molecular Formula: C10H9 N3 S
• Molecular Weight: 0
• Hs Code.: 2933990090
• Mol file: 88579-39-9.mol

Synonyms:HE 10004;Tasuldine

Chemical Property of Tasuldine

Chemical Property:

• Vapor Pressure: 1.34E-05mmHg at 25°C
• Boiling Point: 378.7°C at 760 mmHg
• Flash Point: 182.8°C
• PSA: 63.97000
• Density: 1.27g/cm³
• LogP: 2.16390

Purity/Quality:

2-(PYRIDIN-3-YLMETHYLTHIO)PYRIMIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tasuldine

There total 2 articles about Tasuldine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-chloropyrimidine (1722-12-9,1195939-87-7) + pyridin-3-yl-methanethiol (17617-05-9) → 2-<(3-pyridinylmethyl)thio>pyrimidine (88579-39-9)

Guidance literature:

pyridin-3-yl-methanethiol; With sodium hydride; In 1,2-dimethoxyethane; mineral oil; at 0 - 20 ℃; for 0.666667h; Inert atmosphere;

2-chloropyrimidine; In 1,2-dimethoxyethane; mineral oil; at 0 - 20 ℃; for 1.16667h; Inert atmosphere;

DOI:10.1021/jacs.8b04530

Reference yield: 60.0%

3-chloromethylpyridinium chloride (6959-48-4) + 2-sulfanylpyrimidine (131242-36-9) → 2-<(3-pyridinylmethyl)thio>pyrimidine (88579-39-9)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 4h; Ambient temperature;

DOI:10.1021/jm00386a018

Reference yield: 83.0%

trifluoromethylsulfonic anhydride (358-23-6) + 2-<(3-pyridinylmethyl)thio>pyrimidine (88579-39-9) + triphenylphosphine (603-35-0) → triphenyl(3-((pyrimidin-2-ylthio)methyl)pyridin-4-yl)phosphonium trifluoromethanesulfonate

Guidance literature:

trifluoromethylsulfonic anhydride; 2-<(3-pyridinylmethyl)thio>pyrimidine; triphenylphosphine; In dichloromethane; at -78 ℃; for 1.08333h; Inert atmosphere;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.8b04530

upstream raw materials:

3-chloromethylpyridinium chloride

2-sulfanylpyrimidine

2-chloropyrimidine

pyridin-3-yl-methanethiol