Gimatecan

Base Information

Chemical Name:Gimatecan
CAS No.:292618-32-7
Molecular Formula:C₂₅H₂₅N₃O₅
Molecular Weight:447.491
Hs Code.:
European Community (EC) Number:695-730-5
UNII:7KKS9R192F
DSSTox Substance ID:DTXSID0057702
NCI Thesaurus Code:C65804
Metabolomics Workbench ID:149929
ChEMBL ID:CHEMBL113051
Mol file:292618-32-7.mol

Synonyms:7-t-butoxyiminomethyl-camptothecin;7-t-butoxyiminomethylcamptothecin;Gimatecan;LBQ707;ST 1481;ST1481

Suppliers and Price of Gimatecan

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
Gimatecan 99.20%
5mg
$ 350.00

American Custom Chemicals Corporation
GIMATECAN 95.00%
1G
$ 1091.48

Total 17 raw suppliers

Chemical Property of Gimatecan

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.667
Boiling Point:780.616 °C at 760 mmHg
PKA:11.20±0.20(Predicted)
Flash Point:425.901 °C
PSA：103.01000
Density:1.38 g/cm³
LogP:3.22860
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:447.17942091
Heavy Atom Count:33
Complexity:948

Purity/Quality:

97% ^*data from raw suppliers

Gimatecan 99.20% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)C=NOC(C)(C)C)O
Isomeric SMILES:CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)/C=N/OC(C)(C)C)O
Recent ClinicalTrials:A Study of Oral Gimatecan in Platinum-Resistant Epithelial Ovarian, Fallopian Tube or Peritoneal Cancer
Recent EU Clinical Trials:'Estudio fase II de Gimatecan (ST1481) como tratamiento de rescate en pacientes con sarcoma de partes blandas avanzado o metastático y recidivados después de un régimen de quimioterapia basado en antraciclinas / ifosfamida'

Technology Process of Gimatecan

There total 4 articles about Gimatecan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 7-formyl-camptothecin

: 39684-28-1
O-(tert-butyl)hydroxylamine hydrochloride

: 292618-32-7
gimatecan

Guidance literature:: With sodium hydroxide; In ethanol; for 2h; Product distribution / selectivity; Reflux; Darkness;

Reference yield: 87.0%

: 39684-28-1
O-(tert-butyl)hydroxylamine hydrochloride

: 84017-99-2
7-(dimethoxymethyl)camptothecin

: 292618-32-7
gimatecan

Guidance literature:: In ethanol; for 4h; Product distribution / selectivity; Reflux; Darkness;

Reference yield:

: anti-7-tert-butoxyiminomethylcamptothecin

: 292618-32-7
gimatecan

Guidance literature:: With hydrogenchloride; In dichloromethane; water; at 20 ℃; for 1h; irradiation with a 125 W Hg high pressure U_.V_. lamp;