(E)-7-tert-butoxyiminomethyl-20-O-(2-methoxyphenylglycyl)succinyl-camptothecin

Base Information

Chemical Name:(E)-7-tert-butoxyiminomethyl-20-O-(2-methoxyphenylglycyl)succinyl-camptothecin
CAS No.:630391-04-7
Molecular Formula:C₃₈H₃₈N₄O₁₀
Molecular Weight:710.741
Hs Code.:

Synonyms:(E)-7-tert-butoxyiminomethyl-20-O-(2-methoxyphenylglycyl)succinyl-camptothecin

Suppliers and Price of (E)-7-tert-butoxyiminomethyl-20-O-(2-methoxyphenylglycyl)succinyl-camptothecin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-7-tert-butoxyiminomethyl-20-O-(2-methoxyphenylglycyl)succinyl-camptothecin

Chemical Property:

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Technology Process of (E)-7-tert-butoxyiminomethyl-20-O-(2-methoxyphenylglycyl)succinyl-camptothecin

There total 4 articles about (E)-7-tert-butoxyiminomethyl-20-O-(2-methoxyphenylglycyl)succinyl-camptothecin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 630391-01-4
(E)-7-tert-butoxyiminomethyl-20-O-(tert-butylglycyl)succinyl-camptothecin

: 90-05-1
2-methoxy-phenol

: 630391-04-7
(E)-7-tert-butoxyiminomethyl-20-O-(2-methoxyphenylglycyl)succinyl-camptothecin

Guidance literature:: (E)-7-tert-butoxyiminomethyl-20-O-(tert-butylglycyl)succinyl-camptothecin; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

2-methoxy-phenol; With dicyclohexyl-carbodiimide; dmap; In dichloromethane; for 24h;

Reference yield:

: 292618-32-7
gimatecan

: 630391-04-7
(E)-7-tert-butoxyiminomethyl-20-O-(2-methoxyphenylglycyl)succinyl-camptothecin

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / pyridine / 22 h / 60 °C

2.1: oxalyl dichloride / dichloromethane / 6 - 8 h / 0 - 20 °C

3.1: triethylamine / dichloromethane / 3 h

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.2: 24 h

With oxalyl dichloride; triethylamine; trifluoroacetic acid; dmap; In pyridine; dichloromethane;

Reference yield:

: 630096-28-5
(E)-7-tert-butoxyiminomethyl-20-O-hemisuccinyl-camptothecin

: 630391-04-7
(E)-7-tert-butoxyiminomethyl-20-O-(2-methoxyphenylglycyl)succinyl-camptothecin

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / dichloromethane / 6 - 8 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 3 h

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.2: 24 h

With oxalyl dichloride; triethylamine; trifluoroacetic acid; In dichloromethane;