Ethyl 2,3-dichloro-4-(4'-hydroxybenzyl)phenoxyacetate

Base Information

Chemical Name:Ethyl 2,3-dichloro-4-(4'-hydroxybenzyl)phenoxyacetate
CAS No.:87181-08-6
Molecular Formula:C17H16Cl2O4
Molecular Weight:355.218
Hs Code.:
DSSTox Substance ID:DTXSID101171611

Synonyms:Ethyl 2,3-dichloro-4-(4'-hydroxybenzyl)phenoxyacetate;SCHEMBL11148393;XWUUOOSVCYSSHX-UHFFFAOYSA-N;DTXSID101171611;87181-08-6;ethyl 2-[2,3-dichloro-4-[(4-hydroxyphenyl)methyl]phenoxy]acetate

Suppliers and Price of Ethyl 2,3-dichloro-4-(4'-hydroxybenzyl)phenoxyacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 2,3-dichloro-4-(4'-hydroxybenzyl)phenoxyacetate

Chemical Property:

XLogP3:5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:354.0425644
Heavy Atom Count:23
Complexity:372

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)COC1=C(C(=C(C=C1)CC2=CC=C(C=C2)O)Cl)Cl

Technology Process of Ethyl 2,3-dichloro-4-(4'-hydroxybenzyl)phenoxyacetate

There total 2 articles about Ethyl 2,3-dichloro-4-(4'-hydroxybenzyl)phenoxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 78235-15-1
ethyl <2,3-dichloro-4-<4-hydroxy-3-<(2-chloroacetyl)aminomethyl>benzyl>phenoxy>acetic acid

: 87181-08-6
ethyl <2,3-dichloro-4-(4-hydroxybenzyl)phenoxy>acetate

Guidance literature:: With sodium tetrahydroborate; trifluoroacetic acid; In dichloromethane; Ambient temperature;
DOI:10.1021/jm00379a016

Reference yield:

: 62967-00-4
2,3-dichloro-4-(4'-hydroxybenzoyl)-phenoxyacetic acid

: 87181-08-6
ethyl <2,3-dichloro-4-(4-hydroxybenzyl)phenoxy>acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / H₂SO₄ / 1,2-dichloro-ethane / Heating

2: 69 percent / NaBH₄, TFA / CH₂Cl₂ / Ambient temperature

With sodium tetrahydroborate; sulfuric acid; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm00379a016

Reference yield:

: 2832-19-1
2-Chloro-N-(hydroxymethyl)acetamide

: 87181-08-6
ethyl <2,3-dichloro-4-(4-hydroxybenzyl)phenoxy>acetate

: 87181-09-7
ethyl <2,3-dichloro-4-<4-hydroxy-3-<(2-chloroacetyl)aminomethyl>benzyl>phenoxy>acetate

Guidance literature:: With sulfuric acid; Yield given. Multistep reaction; 1.) AcOH, RT, overnight, 2.) EtOH, RT, overnight;
DOI:10.1021/jm00379a016