3'-Amino-2',3'-dideoxy-5-methylcytidine

Base Information

• Chemical Name: 3'-Amino-2',3'-dideoxy-5-methylcytidine
• CAS No.: 87190-81-6
• Molecular Formula: C₁₀H₁₆N₄O₃
• Molecular Weight: 240.262
• Mol file: 87190-81-6.mol

Synonyms:3'-Amino-2',3'-dideoxy-5-methyl cytidine;3'-Amino-2',3'-didesoxy-5-methyl-cytidin;

Chemical Property of 3'-Amino-2',3'-dideoxy-5-methylcytidine

Chemical Property:

• PSA: 116.39000
• LogP: 0.02250

Purity/Quality:

97% ^*data from raw suppliers

3'-AMINO-2',3'-DIDEOXY-5-METHYLCYTIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-Amino-2',3'-dideoxy-5-methylcytidine

There total 4 articles about 3'-Amino-2',3'-dideoxy-5-methylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3'-azido-5-methyl-2',3'-dideoxycytidine (87190-79-2) → 3'-amino-2',3'-dideoxy-5-methylcytidine (87190-81-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 5h; under 2585.7 Torr;

DOI:10.1021/jm00366a006

Reference yield:

1-(5-O-Acetyl-3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)-5-methyl-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidinone (87190-77-0) → 3'-amino-2',3'-dideoxy-5-methylcytidine (87190-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / aq. NH₄OH / dioxane / 4 h / Ambient temperature

2: 70 percent / H₂ / 10percent Pd/C / ethanol / 5 h / 2585.7 Torr

With ammonium hydroxide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; ethanol;

DOI:10.1021/jm00366a006

Reference yield:

1-(5′-O-acetyl-3′-azido-2′,3′-dideoxy-β-D-ribofuranosyl)thymine (66323-42-0) → 3'-amino-2',3'-dideoxy-5-methylcytidine (87190-81-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 4-chlorophenyl phosphorodichloridate, pyridine / 72 h / Ambient temperature

2: 85 percent / aq. NH₄OH / dioxane / 4 h / Ambient temperature

3: 70 percent / H₂ / 10percent Pd/C / ethanol / 5 h / 2585.7 Torr

With pyridine; ammonium hydroxide; hydrogen; 4-chlorophenylphosphorodichloridate; palladium on activated charcoal; In 1,4-dioxane; ethanol;

DOI:10.1021/jm00366a006

upstream raw materials:

3'-azido-5-methyl-2',3'-dideoxycytidine

1-(5-O-Acetyl-3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)-5-methyl-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidinone

1-(5′-O-acetyl-3′-azido-2′,3′-dideoxy-β-D-ribofuranosyl)thymine

Refernces