3-bromoadamantane-1-carboxamide

Base Information

• Chemical Name: 3-bromoadamantane-1-carboxamide
• CAS No.: 53263-89-1
• Molecular Formula: C₁₁H₁₆BrNO
• Molecular Weight: 258.158
• Hs Code.: 2924299090
• Mol file: 53263-89-1.mol

Synonyms:1-Adamantanecarboxamide,3-bromo- (7CI);3-Bromo-1-adamantanecarboxamide;3-Bromoadamantanecarboxylamide;

Chemical Property of 3-bromoadamantane-1-carboxamide

Chemical Property:

• Vapor Pressure: 2.9E-06mmHg at 25°C
• Refractive Index: 1.635
• Boiling Point: 389.2 °C at 760 mmHg
• PKA: 16.60±0.40(Predicted)
• Flash Point: 189.2 °C
• PSA: 43.09000
• Density: 1.596g/cm³
• LogP: 2.90590

Purity/Quality:

99% ^*data from raw suppliers

3-Bromoadamantane-1-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-bromoadamantane-1-carboxamide

There total 4 articles about 3-bromoadamantane-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

piperidine (110-89-4) + carbon monoxide (201230-82-2) + adamantane-1-carboxamide (5511-18-2) → 1,3-Ad'(CONH2)(NC5H10) + 1,3-Ad'(CONH2)(CONC5H10) (1214747-90-6) + 1-bromo-3-carboxamidoadamantane (53263-89-1)

Guidance literature:

carbon monoxide; adamantane-1-carboxamide; With 2AlBr₃*CBr₄; 1,1-dibromomethane; at 0 - 20 ℃; under 760.051 Torr;

piperidine; With carbon monoxide; at -20 - 0 ℃; under 760.051 Torr;

DOI:10.1016/j.tetlet.2009.12.022

Reference yield:

carbon monoxide (201230-82-2) + adamantane-1-carboxamide (5511-18-2) + isopropyl alcohol (67-63-0,8013-70-5) → 1,3-Ad(CONH2)(COOPr(i)) + 1-bromo-3-carboxamidoadamantane (53263-89-1)

Guidance literature:

carbon monoxide; adamantane-1-carboxamide; With 2AlBr₃*CBr₄; 1,1-dibromomethane; at 0 - 20 ℃; under 760.051 Torr;

isopropyl alcohol; With carbon monoxide; at 0 ℃; for 4h; under 760.051 Torr;

DOI:10.1016/j.tetlet.2009.12.022

Reference yield:

3-bromoadamantane-1-carboxylic acid (21816-08-0) → 1-bromo-3-carboxamidoadamantane (53263-89-1)

Guidance literature:

Multistep reaction; (i) SOBr₂, (ii) NH₃;

DOI:10.1002/hlca.19760590609

upstream raw materials:

3-bromoadamantane-1-carboxylic acid

piperidine

carbon monoxide

adamantane-1-carboxamide

Refernces