Pyrazolo[1,5-d][1,2,4]triazin-4(5H)-one, 3-(1,1-dimethylethyl)-7-(5-methyl-3-isoxazolyl)-2-[[(4-methylphenyl)sulfon yl]oxy]-

Base Information

• Chemical Name: Pyrazolo[1,5-d][1,2,4]triazin-4(5H)-one, 3-(1,1-dimethylethyl)-7-(5-methyl-3-isoxazolyl)-2-[[(4-methylphenyl)sulfon yl]oxy]-
• CAS No.: 875498-37-6
• Molecular Formula: C₂₀H₂₁N₅O₅S
• Molecular Weight: 443.483
• Mol file: 875498-37-6.mol

Synonyms:

Chemical Property of Pyrazolo[1,5-d][1,2,4]triazin-4(5H)-one, 3-(1,1-dimethylethyl)-7-(5-methyl-3-isoxazolyl)-2-[[(4-methylphenyl)sulfon yl]oxy]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyrazolo[1,5-d][1,2,4]triazin-4(5H)-one, 3-(1,1-dimethylethyl)-7-(5-methyl-3-isoxazolyl)-2-[[(4-methylphenyl)sulfon yl]oxy]-

There total 3 articles about Pyrazolo[1,5-d][1,2,4]triazin-4(5H)-one, 3-(1,1-dimethylethyl)-7-(5-methyl-3-isoxazolyl)-2-[[(4-methylphenyl)sulfon yl]oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

toluene-4-sulfonic acid 4-tert-butyl-5-[N'-(5-methyl-isoxazole-3-carbonyl)-hydrazinocarbonyl]-1H-pyrazol-3-yl ester (875489-17-1) → toluene-4-sulfonic acid 4-tert-butyl-5-[5-(5-methyl-isoxazol-3-yl)-[1,3,4]oxadiazol-2-yl]-1H-pyrazol-3-yl ester + toluene-4-sulfonic acid 3-tert-butyl-7-(5-methyl-isoxazol-3-yl)-4-oxo-4,5-dihydro-pyrazolo[1,5-d][1,2,4]triazin-2-yl ester (875498-37-6)

Guidance literature:

In 1,3,5-trimethyl-benzene; at 165 ℃;

DOI:10.1016/j.bmcl.2005.11.012

Reference yield:

4-tert-Butyl-5-formyl-3-[(4-methylphenyl)sulphonyloxy]pyrazole (265643-79-6) → toluene-4-sulfonic acid 3-tert-butyl-7-(5-methyl-isoxazol-3-yl)-4-oxo-4,5-dihydro-pyrazolo[1,5-d][1,2,4]triazin-2-yl ester (875498-37-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / AgNO₃; KOH

2: 57 percent / BOPCl; Et₃N

3: 16 percent / 1,3,5-trimethyl-benzene / 165 °C

With potassium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; silver nitrate; triethylamine; In 1,3,5-trimethyl-benzene;

DOI:10.1016/j.bmcl.2005.11.012

Reference yield:

4-tert-butyl-5-(toluene-4-sulfonyloxy)-2H-pyrazole-3-carboxylic acid (875489-16-0) → toluene-4-sulfonic acid 3-tert-butyl-7-(5-methyl-isoxazol-3-yl)-4-oxo-4,5-dihydro-pyrazolo[1,5-d][1,2,4]triazin-2-yl ester (875498-37-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / BOPCl; Et₃N

2: 16 percent / 1,3,5-trimethyl-benzene / 165 °C

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In 1,3,5-trimethyl-benzene;

DOI:10.1016/j.bmcl.2005.11.012

upstream raw materials:

toluene-4-sulfonic acid 4-tert-butyl-5-[N'-(5-methyl-isoxazole-3-carbonyl)-hydrazinocarbonyl]-1H-pyrazol-3-yl ester

4-tert-Butyl-5-formyl-3-[(4-methylphenyl)sulphonyloxy]pyrazole

4-tert-butyl-5-(toluene-4-sulfonyloxy)-2H-pyrazole-3-carboxylic acid