1H-Indole-2-sulfonyl chloride, 5-fluoro-1-(phenylsulfonyl)-

Base Information

Chemical Name:1H-Indole-2-sulfonyl chloride, 5-fluoro-1-(phenylsulfonyl)-
CAS No.:875573-32-3
Molecular Formula:C14H9ClFNO4S2
Molecular Weight:373.813
Hs Code.:

Synonyms:

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Chemical Property of 1H-Indole-2-sulfonyl chloride, 5-fluoro-1-(phenylsulfonyl)-

Chemical Property:

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Technology Process of 1H-Indole-2-sulfonyl chloride, 5-fluoro-1-(phenylsulfonyl)-

There total 3 articles about 1H-Indole-2-sulfonyl chloride, 5-fluoro-1-(phenylsulfonyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 99532-44-2
1-(benzenesulfonyl)-5-fluoro-1H-indole

: 875573-32-3
(5-fluoro-1-phenylsulfonylindol-2-yl)sulfonyl chloride

Guidance literature:: 1-(benzenesulfonyl)-5-fluoro-1H-indole; With tert.-butyl lithium; In tetrahydrofuran; diethyl ether; pentane; at -78 - 0 ℃;

With sulfur dioxide; In tetrahydrofuran; diethyl ether; pentane; at -78 - 20 ℃;

With N-chloro-succinimide; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1016/j.bmc.2005.09.056

Reference yield:

: 399-52-0
5-fluoro-1H-indole

: 875573-32-3
(5-fluoro-1-phenylsulfonylindol-2-yl)sulfonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / n-butyl lithium / tetrahydrofuran; hexane / 3 h / -78 - 20 °C

2.1: tert-butyl lithium / diethyl ether; tetrahydrofuran; pentane / -78 - 0 °C

2.2: SO₂ / diethyl ether; tetrahydrofuran; pentane / -78 - 20 °C

2.3: 100 percent / N-chlorosuccinimide / CH₂Cl₂ / 20 h / 20 °C

With n-butyllithium; tert.-butyl lithium; In tetrahydrofuran; diethyl ether; hexane; pentane;
DOI:10.1016/j.bmc.2005.09.056

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 875573-32-3
(5-fluoro-1-phenylsulfonylindol-2-yl)sulfonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / n-butyl lithium / tetrahydrofuran; hexane / 3 h / -78 - 20 °C

2.1: tert-butyl lithium / diethyl ether; tetrahydrofuran; pentane / -78 - 0 °C

2.2: SO₂ / diethyl ether; tetrahydrofuran; pentane / -78 - 20 °C

2.3: 100 percent / N-chlorosuccinimide / CH₂Cl₂ / 20 h / 20 °C

With n-butyllithium; tert.-butyl lithium; In tetrahydrofuran; diethyl ether; hexane; pentane;
DOI:10.1016/j.bmc.2005.09.056