99532-44-2

Basic information

• Product Name: 5-fluoro-1-phenylsulfonyl-1H-indole
• Synonyms: 5-fluoro-1-phenylsulfonyl-1H-indole
• CAS NO: 99532-44-2
• Molecular Formula: C₁₄H₁₀FNO₂S
• Molecular Weight: 275
• Mol File: 99532-44-2.mol
• Article Data: 20

Chemical Properties

• Melting Point: 119-121 °C
• Boiling Point: 455.1±37.0 °C(Predicted)
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-fluoro-1-phenylsulfonyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-1-phenylsulfonyl-1H-indole(99532-44-2)
• EPA Substance Registry System: 5-fluoro-1-phenylsulfonyl-1H-indole(99532-44-2)

Safety Data

• Hazardous Substances Data: 99532-44-2(Hazardous Substances Data)

Upstream product

• 399-52-0 5-fluoro-1H-indole 
• 98-09-9 benzenesulfonyl chloride 
• 95-20-5 2-methyl-1H-indole 

Downstream Products

• 99532-53-3 1-(5-fluoro-1H-indol-3-yl)ethan-1-one 
• 220943-23-7 5-fluoro-1H-indole-2-carboxaldehyde 
• 700836-87-9 5-fluoro-2-methyl-1-(phenylsulfonyl)indole 
• 1572177-88-8 5-fluoro-2-iodo-1-(phenylsulfonyl)-1H-indole 
• 1332526-45-0 (5-fluoro-1H-indol-2-yl)(3,4,5-trimethoxyphenyl)methanone 
• 1332526-38-1 (5-fluoro-1-(phenylsulfonyl)-1H-indol-2-yl)(3,4,5-trimethoxyphenyl)methanone 
• 843652-88-0 3-chloro-1-[5-fluoro-1-(phenylsulfonyl)-1H-indol-3-yl]propan-1-one 
• 1033820-36-8 4-[(1-benzenesulfonyl-5-fluoro-1H-indol-2-yl)-hydroxy-methyl]-4-propyl-piperidine-1-carboxylic acid tert-butyl ester 
• 1026089-07-5 3-bromo-5-fluoro-1-(phenylsulfonyl)-1H-indole 
• 875573-34-5 1-[(5-fluoro-1-phenylsulfonylindol-2-yl)sulfonyl]piperazine 
• 896137-95-4 (5-fluoro-1-phenylsulfonyl-1H-indol-2-yl)-(4-methyl-1-phenylsulfonyl-1H-indol-2-yl)methanone 

Relevant articles and documents

Construction of Oxepino[3,2-b]indoles via [4+3] Annulation of 2-Ylideneoxindoles with Crotonate-Derived Sulfur Ylides

A [4+3] annulation of 2-ylideneoxindoles with crotonate-derived sulfur ylides has been developed. A series of oxepino[3,2-b]indoles were prepared in moderate to excellent yields (62-93%) under mild conditions. Moreover, the synthetic oxepino[3,2-b] indoles can be further transformed into more complex cyclopropa[5,6]oxepino[3,2-b]indoles via a [2+1] cyclopropanation. In addition, the synthetic compounds show certain antiproliferative activity against K562 and MCF-7 cells, and its IC50 values for these two kinds of tumor cells up to 5.40±0.88 μM and 18.41±0.50 μM, respectively. (Figure presented.).

HETEROCYCLIC COMPOUNDS AS PAD INHIBITORS

Heterocyclic compounds of Formula (I), (II), and (III) are described herein along with their polymorphs, stereoisomers, prodrugs, solvates, co-crystals, intermediates, pharmaceutically acceptable salts, and metabolites thereof. The compounds described herein, their polymorphs, stereoisomers, prodrugs, solvates, co-crystals, intermediates, pharmaceutically acceptable salts, and metabolites thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosis, cutaneous lupus erythematosis, ulcerative colitis, cancer, cystic fibrosis, asthma, multiple sclerosis and psoriasis.

A short synthesis of 9-fluoroellipticine from 5-fluoroindole?

A synthesis of 9-fluoroellipticine (1c) from 5-fluoroindole (6) is described that features the regioselective lithiation of 5-fluoro-1-(phenylsulfonyl)indole (7) followed by chemoselective acylation of 3,4-pyridinedicarboxylic anhydride. Subsequent cyclization of keto acid 9 to keto lactam 10 with acetic anhydride and sequential treatment of 10 with methyllithium and sodium borohydride affords 9-fluoroellipticine.