1(2H)-Isoquinolinone, 5,6,7-trimethoxy-2-methyl-

Base Information

Chemical Name:1(2H)-Isoquinolinone, 5,6,7-trimethoxy-2-methyl-
CAS No.:23434-97-1
Molecular Formula:C₁₃H₁₅NO₄
Molecular Weight:249.266
Hs Code.:2933790090
DSSTox Substance ID:DTXSID60177989
Nikkaji Number:J16.760F
Wikidata:Q83048333
Mol file:23434-97-1.mol

Synonyms:23434-97-1;1(2H)-Isoquinolinone, 5,6,7-trimethoxy-2-methyl-;5,6,7-Trimethoxy-2-methyl-1(2H)-isoquinolinone;Thalactamine;DTXSID60177989

Suppliers and Price of 1(2H)-Isoquinolinone, 5,6,7-trimethoxy-2-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1(2H)-Isoquinolinone, 5,6,7-trimethoxy-2-methyl-

Chemical Property:

Vapor Pressure:5.52E-08mmHg at 25°C
Melting Point:112-114 °C
Boiling Point:441.3°Cat760mmHg
PKA:-2.22±0.70(Predicted)
Flash Point:220.7°C
PSA：49.69000
Density:1.191g/cm³
LogP:1.56430
XLogP3:1.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:249.10010796
Heavy Atom Count:18
Complexity:344

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C=CC2=C(C(=C(C=C2C1=O)OC)OC)OC
Description The aerial portions of Thalictrum minus yield this alkaloid which has been shown to possess the structure of 1: 2-dihydro-5: 6: 7-trimethoxy-2-methyl-loxoisoquinoline. It gives an ultraviolet spectrum in EtOH with absorption maxima at 247, 270, 281, 293 and 332 nm. The base is stable to both acid and alkaline hydrolysis and hydrogenation with LiAlH4,NaBH4 or PtO2 up to 100°C but catalytic hydrogenation at 80°C and 80 atmospheres furnishes the dihydro derivative, m.p. 104-6°C.

Technology Process of 1(2H)-Isoquinolinone, 5,6,7-trimethoxy-2-methyl-

There total 7 articles about 1(2H)-Isoquinolinone, 5,6,7-trimethoxy-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 26829-55-0
5,6,7-trimethoxyisoquinolin-1(2H)-one

: 74-88-4
methyl iodide

: 23434-97-1
thalactamine

Guidance literature:: With sodium hydroxide; In methanol; at 70 ℃; for 20h; Sealed tube; Schlenk technique; Inert atmosphere;
DOI:10.1039/c5cc04211a

Reference yield:

: C₁₅H₂₁NO₅

: 23434-97-1
thalactamine

Guidance literature:: With trifluoroacetic acid; In 1,4-dioxane; water; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.tet.2020.131150

Reference yield:

: 25563-19-3
N,3,4,5-tetramethoxybenzamide

: 23434-97-1
thalactamine

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate / methanol / 8 h / 30 °C / Inert atmosphere; Schlenk technique; Sealed tube

2: palladium dichloride; copper(l) chloride; oxygen; trimethyleneglycol / 1,2-dimethoxyethane / 24 h / 60 °C / Sealed tube; Schlenk technique

3: sodium hydroxide / methanol / 20 h / 70 °C / Sealed tube; Schlenk technique; Inert atmosphere

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; oxygen; cesium acetate; copper(l) chloride; sodium hydroxide; palladium dichloride; trimethyleneglycol; In methanol; 1,2-dimethoxyethane;
DOI:10.1039/c5cc04211a