4-Pentynoic acid, 5-[4-(trifluoromethyl)phenyl]-

Base Information

Chemical Name:4-Pentynoic acid, 5-[4-(trifluoromethyl)phenyl]-
CAS No.:876049-26-2
Molecular Formula:C12H9F3O2
Molecular Weight:242.197
Hs Code.:

Synonyms:

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Chemical Property of 4-Pentynoic acid, 5-[4-(trifluoromethyl)phenyl]-

Chemical Property:

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Technology Process of 4-Pentynoic acid, 5-[4-(trifluoromethyl)phenyl]-

There total 7 articles about 4-Pentynoic acid, 5-[4-(trifluoromethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 500709-28-4
5-(4-(trifluoromethyl)phenyl)pent-4-yn-1-ol

: 876049-26-2
5-(4-(trifluoromethyl)phenyl)pent-4-ynoic acid

Guidance literature:: With Jones reagent; In acetone; at 0 ℃;
DOI:10.1021/jo4028006

Reference yield:

: ethyl 5-(4-trifluoromethylphenyl)pent-4-ynoate

: 876049-26-2
5-(4-(trifluoromethyl)phenyl)pent-4-ynoic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 3h;
DOI:10.1002/adsc.201100038

Reference yield:

: 6089-09-4
4-pentynoic acid

: 876049-26-2
5-(4-(trifluoromethyl)phenyl)pent-4-ynoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 24 h / 20 °C

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diethylamine / 2 h / 20 °C

3: potassium hydroxide / tetrahydrofuran; water / 3 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; diethylamine; potassium hydroxide; In tetrahydrofuran; water; 2: Sonogashira coupling;
DOI:10.1002/adsc.201100038