[1-(4-Chlorophenyl)-2-methylpropan-2-yl]azanium;chloride

Base Information

• Chemical Name: [1-(4-Chlorophenyl)-2-methylpropan-2-yl]azanium;chloride
• CAS No.: 151-06-4
• Molecular Formula: C10H14 Cl N . Cl H
• Molecular Weight: 220.142
• Hs Code.: 2921499090
• Mol file: 151-06-4.mol

Synonyms:[1-(4-chlorophenyl)-2-methylpropan-2-yl]azanium;chloride

Chemical Property of [1-(4-Chlorophenyl)-2-methylpropan-2-yl]azanium;chloride

Chemical Property:

• Vapor Pressure: 0.016mmHg at 25°C
• Melting Point: 234℃
• Boiling Point: 255.8°Cat760mmHg
• Flash Point: 127°C
• PSA: 26.02000
• Density: g/cm³
• LogP: 4.12210
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 219.0581549
• Heavy Atom Count: 13
• Complexity: 137

Purity/Quality:

97% ^*data from raw suppliers

ChlorphentermineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(CC1=CC=C(C=C1)Cl)[NH3+].[Cl-]
• Uses: chlorphentermine hydrochloride is an anorectic agent. Chlorphentermine is the 4-chloro derivative of the better known appetite suppressant Phentermine (P318830). chlorphentermine hydrochloride is structurally related to amphetamine but is a relatively weak stimulant with little abuse potential.

Technology Process of [1-(4-Chlorophenyl)-2-methylpropan-2-yl]azanium;chloride

There total 2 articles about [1-(4-Chlorophenyl)-2-methylpropan-2-yl]azanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorobenzylmagnesium chloride (874-72-6) → chlorphentermine hydrochloride (151-06-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / diethyl ether / 12 h / 25 °C

2: 1.) NaCN, AcOH, conc. H₂SO₄, 2.) HCl / 1.) 70 deg C, 2 h, 2.) ether

With hydrogenchloride; sulfuric acid; sodium cyanide; acetic acid; In diethyl ether;

DOI:10.1080/00397919908086248

Reference yield:

1-(4-chlorophenyl)-2-methyl-2-propanol (5468-97-3) → chlorphentermine hydrochloride (151-06-4)

Guidance literature:

With hydrogenchloride; sulfuric acid; sodium cyanide; acetic acid; Yield given; Multistep reaction; 1.) 70 deg C, 2 h, 2.) ether;

DOI:10.1080/00397919908086248

Reference yield:

CYANAMID (420-04-2) + chlorphentermine hydrochloride (151-06-4) → N-[2-(4-Chloro-phenyl)-1,1-dimethyl-ethyl]-guanidine (51026-12-1)

Guidance literature:

In water; at 20 - 180 ℃;

DOI:10.1021/jm00312a006

upstream raw materials:

1-(4-chlorophenyl)-2-methyl-2-propanol

4-chlorobenzylmagnesium chloride

Downstream raw materials:

N-[2-(4-Chloro-phenyl)-1,1-dimethyl-ethyl]-guanidine

N-(4-chloro-α,α-dimethylphenethyl) acrylamide

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