2,4(1H,3H)-Pyrimidinedione, 1-(2,3-dideoxy-3-fluoro-b-D-erythro-pentofuranosyl)-

Base Information

Chemical Name:2,4(1H,3H)-Pyrimidinedione, 1-(2,3-dideoxy-3-fluoro-b-D-erythro-pentofuranosyl)-
CAS No.:207128-22-1
Molecular Formula:C9H11FN2O4
Molecular Weight:230.1930432
Hs Code.:

Synonyms:1-(2,3-dideoxy-3-fluoro-β-L-ribofuranosyl)uracil;1-((2S,4R,5S)-4-Fluoro-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione;

Suppliers and Price of 2,4(1H,3H)-Pyrimidinedione, 1-(2,3-dideoxy-3-fluoro-b-D-erythro-pentofuranosyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 2,4(1H,3H)-Pyrimidinedione, 1-(2,3-dideoxy-3-fluoro-b-D-erythro-pentofuranosyl)-

Chemical Property:

PSA：84.32000
LogP:-0.84550

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,4(1H,3H)-Pyrimidinedione, 1-(2,3-dideoxy-3-fluoro-b-D-erythro-pentofuranosyl)-

There total 9 articles about 2,4(1H,3H)-Pyrimidinedione, 1-(2,3-dideoxy-3-fluoro-b-D-erythro-pentofuranosyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.7%

: 207128-21-0
1-((2S,4R,5S)-4-Fluoro-5-trityloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

: 207128-22-1,178374-44-2
β-2',3'-dideoxy-3'-fluoro-L-uridine

Guidance literature:: In acetic acid; at 90 ℃; for 1h;
DOI:10.1021/jm9704210

Reference yield: 23.0%

: 73416-11-2
bis-trimethylsilyluracil

: 302335-76-8
methyl 5-O-benzoyl-2,3-dideoxy-3-fluoro-α/β-L-ribofuranoside

: 207128-22-1,178374-44-2
β-2',3'-dideoxy-3'-fluoro-L-uridine

: 178374-44-2
α-2',3'-dideoxy-3'-fluoro-L-uridine

Guidance literature:: bis-trimethylsilyluracil; methyl 5-O-benzoyl-2,3-dideoxy-3-fluoro-α/β-L-ribofuranoside; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 12h;

With ammonia; In methanol; at 20 ℃; for 12h;
DOI:10.1016/S0008-6215(99)00312-2

Reference yield:

: 207128-16-3
Methanesulfonic acid (2S,3R,5S)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester

: 207128-22-1,178374-44-2
β-2',3'-dideoxy-3'-fluoro-L-uridine

Guidance literature:: Multi-step reaction with 3 steps

1: 46.6 percent / NaOH / ethanol / 2 h / Heating

2: 47.7 percent / DAST / CH₂Cl₂ / 1 h / Ambient temperature

3: 87.7 percent / aq. acetic acid / 1 h / 90 °C

With sodium hydroxide; 4,4'-diaminostilbene-2,2'-disulfonic acid; In ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm9704210