Methanesulfonic acid (2S,3R,5S)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: Methanesulfonic acid (2S,3R,5S)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester
• CAS No.: 207128-16-3
• Molecular Formula: C₂₉H₂₈N₂O₇S
• Molecular Weight: 548.617
• Mol file: 207128-16-3.mol

Synonyms:Methanesulfonic acid (2S,3R,5S)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester

Chemical Property of Methanesulfonic acid (2S,3R,5S)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (2S,3R,5S)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester

There total 3 articles about Methanesulfonic acid (2S,3R,5S)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trityl chloride (76-83-5) → Methanesulfonic acid (2S,3R,5S)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester (207128-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 1 h / 100 °C

2: pyridine / Ambient temperature

With pyridine;

DOI:10.1021/jm9704210

Reference yield:

L-Deoxyuridine (951-78-0,4449-42-7,4481-11-2,13039-99-1,31501-19-6,41545-92-0,41546-05-8,88494-09-1,63844-76-8) → Methanesulfonic acid (2S,3R,5S)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester (207128-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 1 h / 100 °C

2: pyridine / Ambient temperature

With pyridine;

DOI:10.1021/jm9704210

Reference yield:

methanesulfonyl chloride (124-63-0) + 5'-O-trityl-2'-deoxy-L-uridine (816429-66-0) → Methanesulfonic acid (2S,3R,5S)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester (207128-16-3)

Guidance literature:

With pyridine; Yield given; Ambient temperature;

DOI:10.1021/jm9704210

upstream raw materials:

methanesulfonyl chloride

5'-O-trityl-2'-deoxy-L-uridine

trityl chloride

L-Deoxyuridine

Downstream raw materials:

1-((2S,4R,5S)-4-Fluoro-5-trityloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

β-2',3'-dideoxy-3'-fluoro-L-uridine

β-L-2',3'-dideoxy-3'-fluorocytidine

1-((2S,4S,5S)-4-Hydroxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione