2-Methylaminopyrimidine

Base Information

• Chemical Name: 2-Methylaminopyrimidine
• CAS No.: 931-61-3
• Molecular Formula: C5H7 N3
• Molecular Weight: 109.131
• Hs Code.: 2933599590
• European Community (EC) Number: 831-153-9
• NSC Number: 102272
• UNII: 8HQB8CU97K
• DSSTox Substance ID: DTXSID40295478
• Nikkaji Number: J2.409.603C
• Wikidata: Q72487416
• Mol file: 931-61-3.mol

Synonyms:2-Methylaminopyrimidine;931-61-3;n-methylpyrimidin-2-amine;N-Methyl-2-Pyrimidinamine;2-Pyrimidinamine, N-methyl-;Methyl-pyrimidin-2-yl-amine;2-(Methylamino)pyrimidine;MFCD00234126;8HQB8CU97K;Pyrimidine, 2-(methylamino)-;NSC-102272;2-Pyrimidinamine, N-methyl- (9CI);2-Pyrimidinamine,N-methyl-;Methylaminopyrimidin;JH4;NSC102272;methyl-2 pyrimidinylamine;methylpyrimidin-2-yl-amine;UNII-8HQB8CU97K;NCIOpen2_001912;SCHEMBL676888;SCHEMBL22004207;DTXSID40295478;AKOS008019353;AB05135;NSC 102272;AM101628;BS-12860;SY109149;CS-0061723;FT-0646733;EN300-43236;F30217;Z54628578;F8880-7050

Chemical Property of 2-Methylaminopyrimidine

Chemical Property:

• Vapor Pressure: 0.141mmHg at 25°C
• Melting Point: 60-62oC
• Boiling Point: 216.3°Cat760mmHg
• PKA: 3.90±0.10(Predicted)
• Flash Point: 84.6°C
• Density: 1.144g/cm³
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 109.063997236
• Heavy Atom Count: 8
• Complexity: 58.7

Purity/Quality:

97% ^*data from raw suppliers

N-methylpyrimidin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=NC=CC=N1

Technology Process of 2-Methylaminopyrimidine

There total 4 articles about 2-Methylaminopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-chloropyrimidine (1722-12-9,1195939-87-7) + methylamine (74-89-5) → N-methylpyrimidin-2-amine (931-61-3)

Guidance literature:

In methanol; at 50 ℃;

DOI:10.1246/bcsj.71.1973

Reference yield: 75.0%

2-amino-1-methylpyrimidin-1-ium iodide → N-methylpyrimidin-2-amine (931-61-3)

Guidance literature:

With sodium hydroxide; In water; at 80 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2013.12.034

Reference yield:

1,2-dihydro-1-methyl-2-iminopyrimidine hydroiodide (62062-31-1) → N-methylpyrimidin-2-amine (931-61-3)

Guidance literature:

With sodium hydroxide;

DOI:10.1039/P19810000331

upstream raw materials:

2-chloropyrimidine

methylamine

1,2-dihydro-1-methyl-2-iminopyrimidine hydroiodide

Downstream raw materials:

Methyl-(1-oxy-pyrimidin-2-yl)-amine

5-bromo-N-methylpyrimidin-2-amine

5-(2-(hex-5-enyloxy)phenyl)-1-methyl-1H-imidazol-2-amine

N-methyl-5-phenylpyrimidin-2-amine