1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3,5-difluorophenyl)methyl]-1-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-3-oxo-3-[(4S)-2-oxo-4-(phenylmethyl)-3-oxazolidinyl]propyl]-4-( 2-propenyloxy)-, 1,1-dimethylethyl ester, (2R,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3,5-difluorophenyl)methyl]-1-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-3-oxo-3-[(4S)-2-oxo-4-(phenylmethyl)-3-oxazolidinyl]propyl]-4-( 2-propenyloxy)-, 1,1-dimethylethyl ester, (2R,4R)-
CAS No.:877078-89-2
Molecular Formula:C38H52F2N2O7Si
Molecular Weight:714.922
Hs Code.:

1-Pyrrolidinecarboxylic acid,
2-[(1S,2S)-2-[(3,5-difluorophenyl)methyl]-1-[[(1,1-dimethylethyl)dimethyl
silyl]oxy]-3-oxo-3-[(4S)-2-oxo-4-(phenylmethyl)-3-oxazolidinyl]propyl]-4-(
2-propenyloxy)-, 1,1-dimethylethyl ester, (2R,4R)-

Synonyms:

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3,5-difluorophenyl)methyl]-1-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-3-oxo-3-[(4S)-2-oxo-4-(phenylmethyl)-3-oxazolidinyl]propyl]-4-( 2-propenyloxy)-, 1,1-dimethylethyl ester, (2R,4R)-

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3,5-difluorophenyl)methyl]-1-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-3-oxo-3-[(4S)-2-oxo-4-(phenylmethyl)-3-oxazolidinyl]propyl]-4-( 2-propenyloxy)-, 1,1-dimethylethyl ester, (2R,4R)-

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3,5-difluorophenyl)methyl]-1-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-3-oxo-3-[(4S)-2-oxo-4-(phenylmethyl)-3-oxazolidinyl]propyl]-4-( 2-propenyloxy)-, 1,1-dimethylethyl ester, (2R,4R)-

There total 3 articles about 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3,5-difluorophenyl)methyl]-1-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-3-oxo-3-[(4S)-2-oxo-4-(phenylmethyl)-3-oxazolidinyl]propyl]-4-( 2-propenyloxy)-, 1,1-dimethylethyl ester, (2R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 877078-48-3
(2R,4R)-tert-butyl 2-((1S,2S)-2-(3,5-difluorobenzyl)-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-1-hydroxy-3-oxopropyl)-4-(allyloxy)pyrrolidine-1-carboxylate

: 69739-34-0
t-butyldimethylsiyl triflate

: 877078-89-2
(2R,4R)-tert-butyl 2-((1S,2S)-2-(3,5-difluorobenzyl)-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-1-(tert-butyldimethylsilyloxy)-3-oxopropyl)-4-(allyloxy)pyrrolidine-1-carboxylate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane;
DOI:10.1016/j.bmcl.2011.06.109

Reference yield:

: 877078-49-4
(S)-4-benzyl-3-(3-(3,5-difluorophenyl)propanoyl)oxazolidin-2-one

: 877078-89-2
(2R,4R)-tert-butyl 2-((1S,2S)-2-(3,5-difluorobenzyl)-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-1-(tert-butyldimethylsilyloxy)-3-oxopropyl)-4-(allyloxy)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

2: 2,6-dimethylpyridine / dichloromethane

With 2,6-dimethylpyridine; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2011.06.109

Reference yield:

: 877078-47-2
(2R,4R)-tert-butyl 4-(allyloxy)-2-formylpyrrolidine-1-carboxylate

: 877078-89-2
(2R,4R)-tert-butyl 2-((1S,2S)-2-(3,5-difluorobenzyl)-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-1-(tert-butyldimethylsilyloxy)-3-oxopropyl)-4-(allyloxy)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

2: 2,6-dimethylpyridine / dichloromethane

With 2,6-dimethylpyridine; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2011.06.109