(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

Base Information

• Chemical Name: (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
• CAS No.: 877397-71-2
• Molecular Formula: C₁₃H₁₁Cl₂FN₂O
• Molecular Weight: 301.148
• Hs Code.: 2933399090
• Mol file: 877397-71-2.mol

Synonyms:3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine;

Chemical Property of (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

Chemical Property:

• PSA: 48.14000
• Density: 1.400
• LogP: 4.83090
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-3-(1-(2,6-Dichloro-3-fluorophenyl)-ethoxy)pyridin-2-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

There total 19 articles about (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethyoxyl)-2-nitropyridine (877397-70-1) → (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethyoxyl)-2-aminopyridine (877397-71-2)

Guidance literature:

With ethanol; iron; at 90 ℃; for 0.333333h;

Reference yield: 99.0%

(±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine (756521-08-1) → (±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine (756520-67-9,877397-71-2)

Guidance literature:

iron; In ethanol; acetic acid; for 1h; Heating / reflux;

Reference yield: 95.0%

(S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine → (S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-aminopyridine (877397-71-2)

Guidance literature:

With iron; acetic acid; In ethanol; at 80 ℃; for 3h; Inert atmosphere;

upstream raw materials:

(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethyoxyl)-2-nitropyridine

(S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol

3-hydroxy-2-nitropyridine

(R)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol

Downstream raw materials:

3-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)pyridin-2-amine