756521-08-1 Usage
Description
3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine is a complex organic compound that belongs to the category of aromatic halogenated compounds and is a sub-category of dipyridines. It features two aromatic rings, one being pyridine and the other phenyl, which are interconnected through an ethoxy linkage. The molecule also contains fluoride, chloride, and nitro functional groups, which contribute to its unique chemical behaviors. Although its physical properties, such as molecular weight, boiling and melting points, or solubility, are not extensively reported in the scientific literature, the presence of halogens suggests it may exhibit significant reactivity. The comprehensive toxicity profile and environmental impact of this substance are also not well documented, indicating that it is either a relatively new compound or not widely used in the chemical industry.
Uses
Used in Chemical Synthesis:
3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine is used as a chemical intermediate for the synthesis of various complex organic molecules. Its unique structure, which includes halogens and nitro groups, makes it a valuable building block in the preparation of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Research and Development:
In the field of organic chemistry, 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine serves as a research compound for studying the reactivity and properties of halogenated aromatic compounds. Its potential applications in the development of new chemical reactions and methodologies are being explored, contributing to the advancement of synthetic chemistry.
Used in Material Science:
3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine is used as a component in the development of new materials with specific properties, such as electronic or optical characteristics. Its incorporation into polymers or other materials can lead to the creation of novel materials with potential applications in various industries, including electronics, photonics, and energy storage.
Check Digit Verification of cas no
The CAS Registry Mumber 756521-08-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,5,6,5,2 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 756521-08:
(8*7)+(7*5)+(6*6)+(5*5)+(4*2)+(3*1)+(2*0)+(1*8)=171
171 % 10 = 1
So 756521-08-1 is a valid CAS Registry Number.
756521-08-1Relevant articles and documents
Discovery of 2-aminopyridines bearing a pyridone moiety as potent ALK inhibitors to overcome the crizotinib-resistant mutants
Chen, Wenteng,Guo, Xiao,Zhang, Can,Ke, Di,Zhang, Guolin,Yu, Yongping
, (2019/10/02)
Despite the initial benefit demonstrated in clinical setting with ALK inhibitors, the challenging resistant mutants (F1174L, L1196M and G1202R) invariably developed. In this work, a series of 2-aminopyridine derivatives were designed and synthesized by C-5 position incorporation of a 2-pyridone moiety and bioisosteric replacement of the C-3 position linkers. Optimization of the 2-aminopyridine derivatives led to the identification of hit 18d displaying a significant growth inhibition against a variety of ALK-addicted cancer cells. Especially in the case of ALK-positive Karpas-299 cell, 18d exhibited excellent anti-proliferative potency with an IC50 value of about 40 nM. Moreover, 18d demonstrated encouraging activities against wild-type ALK (19 nM), ROS1 (2.3 nM) as well as challenging crizotinib-resistant ALKL1196M and ALKG1202R mutants with IC50 values of 45 nM and 22 nM, respectively. Additionally flow cytometric analysis indicates that 18d inhibited Karpas-299 cell viability via G1 phase arrest. Taken together, this work provided a promising ALK inhibitor to circumvent the clinical crizotinib-resistant mutants.
Inhibitors of nedd8-activating enzyme
-
, (2014/08/20)
The invention relates to an administration unit comprising crystalline form I of {(1 S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate (I-216) hydrochloride salt and to a packaging comprising the administration unit according to the invention.
Aminoheteroaryl compounds and preparation method and use thereof
-
, (2014/12/09)
The present invention refers to aminoheteroaryl compounds of the following formula (I) as well as the preparation method and use thereof, wherein R1 and R3 are defined in the Description in details. The aminoheteroaryl compounds of t
