Technology Process of Oxiranecarboxylic acid,
3-[1-[(2,4-dichlorophenyl)methyl]-6-(trifluoromethyl)-1H-indazol-3-yl]-
There total 10 articles about Oxiranecarboxylic acid,
3-[1-[(2,4-dichlorophenyl)methyl]-6-(trifluoromethyl)-1H-indazol-3-yl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dihydrogen peroxide; sodium hydroxide;
In
methanol; water;
at 20 ℃;
for 6h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: dimethyl sulfoxide; sodium chloride / water / 120 °C
2.1: hydrogen / 5% Pd(II)/C(eggshell) / toluene / 20 °C / 760.05 Torr
3.1: tert.-butylnitrite; acetic acid / 2.17 h / 90 - 95 °C / Cooling with ice
4.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 90 °C
5.1: diisobutylaluminium hydride / dichloromethane / 2.25 h / -78 °C / Inert atmosphere
5.2: -78 °C
6.1: manganese(IV) oxide / dichloromethane / 20 °C
7.1: dichloromethane / Reflux
8.1: water; lithium hydroxide / tetrahydrofuran; methanol / 40 °C
8.2: 0 °C / pH 2
9.1: sodium hydroxide; dihydrogen peroxide / water; methanol / 6 h / 20 °C
With
manganese(IV) oxide; tert.-butylnitrite; water; hydrogen; dihydrogen peroxide; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; sodium chloride; sodium hydroxide; lithium hydroxide;
5% Pd(II)/C(eggshell);
In
tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: hydrogen / 5% Pd(II)/C(eggshell) / toluene / 20 °C / 760.05 Torr
2.1: tert.-butylnitrite; acetic acid / 2.17 h / 90 - 95 °C / Cooling with ice
3.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 90 °C
4.1: diisobutylaluminium hydride / dichloromethane / 2.25 h / -78 °C / Inert atmosphere
4.2: -78 °C
5.1: manganese(IV) oxide / dichloromethane / 20 °C
6.1: dichloromethane / Reflux
7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 40 °C
7.2: 0 °C / pH 2
8.1: sodium hydroxide; dihydrogen peroxide / water; methanol / 6 h / 20 °C
With
manganese(IV) oxide; tert.-butylnitrite; water; hydrogen; dihydrogen peroxide; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; potassium carbonate; acetic acid; sodium hydroxide; lithium hydroxide;
5% Pd(II)/C(eggshell);
In
tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;
