Technology Process of 1H-Indazole-3-propanoic acid,
1-[(2,4-dichlorophenyl)methyl]-6-(trifluoromethyl)-
There total 10 articles about 1H-Indazole-3-propanoic acid,
1-[(2,4-dichlorophenyl)methyl]-6-(trifluoromethyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
5% Pd(II)/C(eggshell);
In
methanol; dichloromethane;
at 20 ℃;
under 760.051 Torr;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: dimethyl sulfoxide; sodium chloride / water / 120 °C
2.1: hydrogen / 5% Pd(II)/C(eggshell) / toluene / 20 °C / 760.05 Torr
3.1: tert.-butylnitrite; acetic acid / 2.17 h / 90 - 95 °C / Cooling with ice
4.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 90 °C
5.1: diisobutylaluminium hydride / dichloromethane / 2.25 h / -78 °C / Inert atmosphere
5.2: -78 °C
6.1: manganese(IV) oxide / dichloromethane / 20 °C
7.1: dichloromethane / Reflux
8.1: water; lithium hydroxide / tetrahydrofuran; methanol / 40 °C
8.2: 0 °C / pH 2
9.1: hydrogen / 5% Pd(II)/C(eggshell) / dichloromethane; methanol / 20 °C / 760.05 Torr
With
manganese(IV) oxide; tert.-butylnitrite; water; hydrogen; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; sodium chloride; lithium hydroxide;
5% Pd(II)/C(eggshell);
In
tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: hydrogen / 5% Pd(II)/C(eggshell) / toluene / 20 °C / 760.05 Torr
2.1: tert.-butylnitrite; acetic acid / 2.17 h / 90 - 95 °C / Cooling with ice
3.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 90 °C
4.1: diisobutylaluminium hydride / dichloromethane / 2.25 h / -78 °C / Inert atmosphere
4.2: -78 °C
5.1: manganese(IV) oxide / dichloromethane / 20 °C
6.1: dichloromethane / Reflux
7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 40 °C
7.2: 0 °C / pH 2
8.1: hydrogen / 5% Pd(II)/C(eggshell) / dichloromethane; methanol / 20 °C / 760.05 Torr
With
manganese(IV) oxide; tert.-butylnitrite; water; hydrogen; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; potassium carbonate; acetic acid; lithium hydroxide;
5% Pd(II)/C(eggshell);
In
tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;