Technology Process of 1H-Indazole-3-propanoic acid,
1-[(2,4-dichlorophenyl)methyl]-5-(trifluoromethyl)-
There total 10 articles about 1H-Indazole-3-propanoic acid,
1-[(2,4-dichlorophenyl)methyl]-5-(trifluoromethyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
5%-palladium/activated carbon;
In
methanol; dichloromethane;
at 20 ℃;
under 760.051 Torr;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium chloride / water; dimethyl sulfoxide / 16 - 20 h / 120 °C
2.1: hydrogen / 5%-palladium/activated carbon / toluene / 1 - 5 h / 20 °C / 760.05 Torr
3.1: tert.-butylnitrite; acetic acid / 1.83 - 2 h / 90 - 95 °C
4.1: potassium carbonate / tetra-(n-butyl)ammonium iodide / acetonitrile / 1 - 2 h / 90 °C / Heating / reflux
5.1: diisobutylaluminium hydride / dichloromethane / 2 - 2.25 h / -78 °C
5.2: -78 °C
6.1: manganese(IV) oxide / dichloromethane / 0.5 - 3 h / 20 °C
7.1: dichloromethane / 3 - 12 h / Heating / reflux
8.1: methanol; lithium hydroxide; water / tetrahydrofuran / 2 - 3 h / 20 - 40 °C
8.2: 0 °C / pH 2
9.1: hydrogen / 5%-palladium/activated carbon / methanol; dichloromethane / 20 °C / 760.05 Torr
With
methanol; manganese(IV) oxide; lithium hydroxide; tert.-butylnitrite; water; hydrogen; diisobutylaluminium hydride; potassium carbonate; acetic acid; sodium chloride;
5%-palladium/activated carbon; tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile;
7.1: Wittig Reaction;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tert.-butylnitrite; acetic acid / 1.83 - 2 h / 90 - 95 °C
2.1: potassium carbonate / tetra-(n-butyl)ammonium iodide / acetonitrile / 1 - 2 h / 90 °C / Heating / reflux
3.1: diisobutylaluminium hydride / dichloromethane / 2 - 2.25 h / -78 °C
3.2: -78 °C
4.1: manganese(IV) oxide / dichloromethane / 0.5 - 3 h / 20 °C
5.1: dichloromethane / 3 - 12 h / Heating / reflux
6.1: methanol; lithium hydroxide; water / tetrahydrofuran / 2 - 3 h / 20 - 40 °C
6.2: 0 °C / pH 2
7.1: hydrogen / 5%-palladium/activated carbon / methanol; dichloromethane / 20 °C / 760.05 Torr
With
methanol; manganese(IV) oxide; lithium hydroxide; tert.-butylnitrite; water; hydrogen; diisobutylaluminium hydride; potassium carbonate; acetic acid;
5%-palladium/activated carbon; tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
5.1: Wittig Reaction;