3(2H)-Pyridazinone,4-chloro-2-methyl-5-[(1E)-3-oxo-3-phenyl-1-propenyl]-

Base Information

• Chemical Name: 3(2H)-Pyridazinone,4-chloro-2-methyl-5-[(1E)-3-oxo-3-phenyl-1-propenyl]-
• CAS No.: 877932-24-6
• Molecular Formula: C14H11ClN2O2
• Molecular Weight: 274.707

Synonyms:3(2H)-Pyridazinone,4-chloro-2-methyl-5-[(1E)-3-oxo-3-phenyl-1-propenyl]-

Chemical Property of 3(2H)-Pyridazinone,4-chloro-2-methyl-5-[(1E)-3-oxo-3-phenyl-1-propenyl]-

Chemical Property:

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Technology Process of 3(2H)-Pyridazinone,4-chloro-2-methyl-5-[(1E)-3-oxo-3-phenyl-1-propenyl]-

There total 1 articles about 3(2H)-Pyridazinone,4-chloro-2-methyl-5-[(1E)-3-oxo-3-phenyl-1-propenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

1-Phenyl-2-propyn-1-ol (4187-87-5) + 4-chloro-2-methyl-5-trifluoromethanesulfonyloxy-3(2H)-pyridazinone (877932-29-1) → 4-chloro-2-methyl-5-(3-oxo-3-phenyl-propenyl)-2H-pyridazin-3-one + 4-chloro-2-methyl-5-(3-oxo-3-phenyl-propenyl)-2H-pyridazin-3-one (877932-24-6)

Guidance literature:

1-Phenyl-2-propyn-1-ol; 4-chloro-2-methyl-5-trifluoromethanesulfonyloxy-3(2H)-pyridazinone; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 20 ℃;

With triethylamine; In 1,4-dioxane; for 24h; Heating;

DOI:10.1016/j.bmcl.2005.10.073

Reference yield: 91.0%

4-chloro-2-methyl-5-(3-oxo-3-phenyl-propenyl)-2H-pyridazin-3-one (877932-24-6) + dimethyl amine (124-40-3) → 4-dimethylamino-2-methyl-5-(3-oxo-3-phenyl-propenyl)-2H-pyridazin-3-one

Guidance literature:

In ethanol; at 20 ℃;

DOI:10.1016/j.bmcl.2005.10.073

Reference yield: 55.0%

4-chloro-2-methyl-5-(3-oxo-3-phenyl-propenyl)-2H-pyridazin-3-one (877932-24-6) + phenylboronic acid (98-80-6) → 2-methyl-5-(3-oxo-3-phenyl-propenyl)-4-phenyl-2H-pyridazin-3-one

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In toluene; Heating;

DOI:10.1016/j.bmcl.2005.10.073

upstream raw materials:

1-Phenyl-2-propyn-1-ol

4-chloro-2-methyl-5-trifluoromethanesulfonyloxy-3(2H)-pyridazinone

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