9-Fluorenylmethyl pentafluorophenyl carbonate

Base Information

• Chemical Name: 9-Fluorenylmethyl pentafluorophenyl carbonate
• CAS No.: 88744-04-1
• Molecular Formula: C21H11 F5 O3
• Molecular Weight: 406.309
• Hs Code.: 29209090
• DSSTox Substance ID: DTXSID40369789
• Nikkaji Number: J402.025A
• Wikidata: Q72515379
• Mol file: 88744-04-1.mol

Synonyms:88744-04-1;9-Fluorenylmethyl pentafluorophenyl carbonate;Fmoc-OPfp;9H-fluoren-9-ylmethyl (2,3,4,5,6-pentafluorophenyl) Carbonate;(9H-Fluoren-9-yl)methyl (perfluorophenyl) carbonate;9-FLUORENYLMETHYLPENTAFLUOROPHENYL CARBONATE;MFCD00013261;C21H11F5O3;carbonic acid 9h-fluoren-9-ylmethyl pentafluorophenyl ester;9-FLUORENYLMETHYLPENTAFLUOROPHENYLCARBONATE;9H-fluoren-9-ylmethyl pentafluorophenyl carbonate;SCHEMBL1401611;DTXSID40369789;CBBKZVZOEBSFQX-UHFFFAOYSA-N;AKOS015840341;AC-7858;CS-W011688;GS-6915;SY017776;F0936;FT-0642101;H10354;(9H-fluoren-9-yl)methyl perfluorophenyl carbonate;9-Fluorenylmethyl pentafluorophenyl carbonate, 98%;A842866;J-520003;Carbonic Acid 9-Fluorenylmethyl Pentafluorophenyl Ester;Carbonic acid (9H-fluoren-9-ylmethyl)pentafluorophenyl ester;(9H-fluoren-9-yl)methyl 2,3,4,5,6-pentafluorophenyl carbonate;FMOC-OPFPCarbonic acid 9H-fluoren-9-ylmethylpentafluorophenyl ester;[1-(9H-fluoren-9-ylmethyl)-2,3,4,5,6-pentafluoro-cyclohexa-2,4-dien-1-yl] carbonate

Chemical Property of 9-Fluorenylmethyl pentafluorophenyl carbonate

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 8.82E-12mmHg at 25°C
• Melting Point: 85-87 °C(lit.)
• Boiling Point: 523.4°C at 760 mmHg
• Flash Point: >110°C
• PSA: 35.53000
• Density: 1.457
• LogP: 5.71000
• Storage Temp.: 0-6°C
• Solubility.: soluble in Chloroform
• XLogP3: 5.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 406.06283502
• Heavy Atom Count: 29
• Complexity: 555

Purity/Quality:

98%,99%, ^*data from raw suppliers

9-Fluorenylmethyl Pentafluorophenyl Carbonate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)OC4=C(C(=C(C(=C4F)F)F)F)F
• Uses: Reagent for amino acid protection-activation.

Technology Process of 9-Fluorenylmethyl pentafluorophenyl carbonate

There total 1 articles about 9-Fluorenylmethyl pentafluorophenyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2,3,4,5,6-pentafluorophenol (771-61-9) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → (9-fluorenyl)methyl pentafluorophenyl carbonate (88744-04-1)

Guidance literature:

With triethylamine; In diethyl ether; at 0 ℃; for 2h;

Reference yield: 93.0%

L-alanin (56-41-7,25191-17-7,18875-37-1) + (9-fluorenyl)methyl pentafluorophenyl carbonate (88744-04-1) → N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; Ambient temperature;

Reference yield: 91.0%

L-glutamic acid 5-tert-butyl ester (2419-56-9) + (9-fluorenyl)methyl pentafluorophenyl carbonate (88744-04-1) → Fmoc-Glu(OtBu)-OH (71989-18-9)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; Ambient temperature;

upstream raw materials:

2,3,4,5,6-pentafluorophenol

(fluorenylmethoxy)carbonyl chloride

Downstream raw materials:

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Fmoc-Val-OH

N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine

Fmoc-Thr-OH

Refernces