Eurystatin A

Base Information

Chemical Name:Eurystatin A
CAS No.:137563-63-4
Molecular Formula:C₂₃H₃₈N₄O₅
Molecular Weight:450.579
Hs Code.:
Nikkaji Number:J518.549A
Wikidata:Q76386704
Mol file:137563-63-4.mol

Synonyms:BU 4164E A;BU-4164E A;eurystatin A

Suppliers and Price of Eurystatin A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
EURYSTATIN A 95.00%
5MG
$ 505.69

Total 2 raw suppliers

Chemical Property of Eurystatin A

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：143.94000
Density:1.13g/cm³
LogP:2.69920
XLogP3:2.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:450.28422033
Heavy Atom Count:32
Complexity:717

Purity/Quality:

95% ^*data from raw suppliers

EURYSTATIN A 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C(=O)C(=O)NC(C(=O)NCCCC(C(=O)N1)NC(=O)C=CCCC(C)C)CC(C)C
Isomeric SMILES:C[C@H]1C(=O)C(=O)N[C@H](C(=O)NCCC[C@@H](C(=O)N1)NC(=O)/C=C/CCC(C)C)CC(C)C

Technology Process of Eurystatin A

There total 25 articles about Eurystatin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 373605-03-9
(E)-6-Methyl-hept-2-enoic acid ((3S,7S,10S)-6-hydroxy-3-isobutyl-7-methyl-2,5,9-trioxo-1,4,8-triaza-cyclotridec-10-yl)-amide

: 137563-63-4
Eurystatin A

Guidance literature:: With sulfur trioxide pyridine complex; triethylamine; In dimethyl sulfoxide; at 5 - 20 ℃;
DOI:10.1016/S0040-4039(01)01287-4

Reference yield:

: 21691-53-2
L-leucine tert-butyl ester

: 137563-63-4
Eurystatin A

Guidance literature:: Multi-step reaction with 6 steps

1.1: CH₂Cl₂ / 1 h / -78 °C

1.2: 7.9877 g / AgNO₃ / tetrahydrofuran; H₂O / 24 h / 20 °C

2.1: H₂ / Pd/C / CH₂Cl₂ / 0.67 h / 20 °C

3.1: 0.1791 g / HOBt; EDCI / CH₂Cl₂ / 2.5 h / 20 °C

4.1: CH₂Cl₂ / 1.5 h / 20 °C

5.1: 2.2192 g / diphenylphosphoryl azide; NaHCO₃ / dimethylformamide / 40 h / -15 °C

6.1: H₂ / Pd/C / CH₂Cl₂; methanol / 15 h / 20 °C

6.2: RDCI / CH₂Cl₂; methanol / 3 h / 20 °C

With diphenylphosphoranyl azide; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(03)00860-3

Reference yield:

: 199467-25-9
(E)-6-methyl-2-heptenoic acid

: 158221-48-8
(3-isobutyl-7-methyl-2,5,6,9-tetraoxo-1,4,8-triazacyclotridec-10-yl)-carbamic acid benzyl ester

: 137563-63-4
Eurystatin A

Guidance literature:: (3-isobutyl-7-methyl-2,5,6,9-tetraoxo-1,4,8-triazacyclotridec-10-yl)-carbamic acid benzyl ester; With hydrogen; palladium on activated charcoal; In methanol; dichloromethane; at 20 ℃; for 15h;

(E)-6-methyl-2-heptenoic acid; In methanol; dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/S0040-4020(03)00860-3