L-LEUCINE TERT-BUTYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: L-LEUCINE TERT-BUTYL ESTER HYDROCHLORIDE
• CAS No.: 21691-53-2
• Molecular Formula: C10H21NO2
• Molecular Weight: 187.282
• Mol file: 21691-53-2.mol

Synonyms:L-leucine tert-butyl ester;dl-leucine ethyl ester hydrochloride;L-Leucine 1,1-dimethylethyl ester;H2N-Leu-OtBu;(L)-leucine ethyl ester hydrochloride;leu-OEt HCl;Ethyl L-leucinate hydrochloride;H-Leu-O-t-Bu;L-leucine ethyl ester HCl;H-Leu-OEt.HCl;H-L-Leu-OtBu;ethyl 2-amino-4-methylpentanoate hydrochloride;(S)-Leu-O-tBu;L-leucine-OEt HCl;

Chemical Property of L-LEUCINE TERT-BUTYL ESTER HYDROCHLORIDE

Chemical Property:

• PSA: 52.32000
• LogP: 3.20380
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

L-Leucinetert-butylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-LEUCINE TERT-BUTYL ESTER HYDROCHLORIDE

There total 11 articles about L-LEUCINE TERT-BUTYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(S)-tert-butyl 2-(benzyloxycarbonylamino)-4-methylpentanoate (16881-37-1) + acetic acid (64-19-7,77671-22-8) → L-leucine tert-butyl ester (21691-53-2)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; for 0.0833333h;

DOI:10.1055/s-1980-29275

Reference yield: 90.0%

acetic acid tert-butyl ester (540-88-5) + L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → L-leucine tert-butyl ester (21691-53-2)

Guidance literature:

With perchloric acid; at 20 ℃; for 16h;

DOI:10.1002/pep2.24260

Reference yield: 81.9%

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) + tert-butyl alcohol (75-65-0) → L-leucine tert-butyl ester (21691-53-2)

Guidance literature:

With acetyl chloride; at 0 - 25 ℃; for 96h; Green chemistry;

upstream raw materials:

L-leucine

isobutene

acetic acid tert-butyl ester

(S)-tert-butyl 2-(benzyloxycarbonylamino)-4-methylpentanoate

Downstream raw materials:

(S)-tert-butyl 2-(2-(((benzyloxy)carbonyl)amino)acetamido)-4-methylpentanoate

N-2-Phenyl-iso-propyloxycarbonyl-alanyl-leucin-tert.-butylester

hZ-Phe-Leu-O-t-Bu

N-<2-<(Dimethyl)(phenyl)phosphonio>isopropyloxy>-L-leucyl-L-leucin-tert-butylester-chlorid