Piperazinone, 6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-5-(1-methylethyl)-4-[(S)-( 4-methylphenyl)sulfinyl]-1-(phenylmethyl)-, (5R,6S)-

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Chemical Name:Piperazinone, 6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-5-(1-methylethyl)-4-[(S)-( 4-methylphenyl)sulfinyl]-1-(phenylmethyl)-, (5R,6S)-
CAS No.:878556-95-7
Molecular Formula:C28H42N2O3SSi
Molecular Weight:514.805
Hs Code.:

Piperazinone,
6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-5-(1-methylethyl)-4-[(S)-(
4-methylphenyl)sulfinyl]-1-(phenylmethyl)-, (5R,6S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Piperazinone, 6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-5-(1-methylethyl)-4-[(S)-( 4-methylphenyl)sulfinyl]-1-(phenylmethyl)-, (5R,6S)-

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Technology Process of Piperazinone, 6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-5-(1-methylethyl)-4-[(S)-( 4-methylphenyl)sulfinyl]-1-(phenylmethyl)-, (5R,6S)-

There total 4 articles about Piperazinone, 6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-5-(1-methylethyl)-4-[(S)-( 4-methylphenyl)sulfinyl]-1-(phenylmethyl)-, (5R,6S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 878556-91-3
(+)-N-benzyl-N-[(1S,2R,S_S)-1-(t-butyldimethylsilyloxymethyl)-3-methyl-2-(p-tolylsulfinylamino)but-1-yl]-2-chloroacetamide

: 878556-95-7
(+)-(5R,6S,S_S)-1-benzyl-6-[(t-butyldimethylsilyloxy)methyl]-5-(i-propyl)-4-(p-tolylsulfinyl)piperazin-2-one

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 2.5h;
DOI:10.1021/jo052077h

Reference yield:

: 878556-88-8
(+)-(1R,2S,S_S)-N-[2-benzylamino-3-(t-butyldimethylsilyloxy)-1-(i-propyl)prop-1-yl]-p-tolylsulfinamide

: 878556-95-7
(+)-(5R,6S,S_S)-1-benzyl-6-[(t-butyldimethylsilyloxy)methyl]-5-(i-propyl)-4-(p-tolylsulfinyl)piperazin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / aq. NaHCO₃ / ethyl acetate / 22 h / 0 - 20 °C

2: 77 percent / Cs₂CO₃ / dimethylformamide / 2.5 h / 65 °C

With sodium hydrogencarbonate; caesium carbonate; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo052077h

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 878556-95-7
(+)-(5R,6S,S_S)-1-benzyl-6-[(t-butyldimethylsilyloxy)methyl]-5-(i-propyl)-4-(p-tolylsulfinyl)piperazin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / imidazole; DMAP / CH₂Cl₂ / 3 h / 20 °C

2: 75 percent / aq. NaHCO₃ / ethyl acetate / 22 h / 0 - 20 °C

3: 77 percent / Cs₂CO₃ / dimethylformamide / 2.5 h / 65 °C

With 1H-imidazole; dmap; sodium hydrogencarbonate; caesium carbonate; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo052077h