3'-Thymidylic acid, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-4-O-[2-(4-nitrophenyl)ethyl]-, mono[2-(4-nitrophenyl)ethyl] ester, compd. with N,N-diethylethanamine (1:1)

Base Information

Chemical Name:3'-Thymidylic acid, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-4-O-[2-(4-nitrophenyl)ethyl]-, mono[2-(4-nitrophenyl)ethyl] ester, compd. with N,N-diethylethanamine (1:1)
CAS No.:87875-22-7
Molecular Formula:C₆H₁₅N*C₄₆H₄₅N₄O₁₃P
Molecular Weight:994.048
Hs Code.:

3'-Thymidylic acid,
5'-O-[(4-methoxyphenyl)diphenylmethyl]-4-O-[2-(4-nitrophenyl)ethyl]-,
mono[2-(4-nitrophenyl)ethyl] ester, compd. with N,N-diethylethanamine
(1:1)

Synonyms:

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Chemical Property of 3'-Thymidylic acid, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-4-O-[2-(4-nitrophenyl)ethyl]-, mono[2-(4-nitrophenyl)ethyl] ester, compd. with N,N-diethylethanamine (1:1)

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Technology Process of 3'-Thymidylic acid, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-4-O-[2-(4-nitrophenyl)ethyl]-, mono[2-(4-nitrophenyl)ethyl] ester, compd. with N,N-diethylethanamine (1:1)

There total 7 articles about 3'-Thymidylic acid, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-4-O-[2-(4-nitrophenyl)ethyl]-, mono[2-(4-nitrophenyl)ethyl] ester, compd. with N,N-diethylethanamine (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 87892-66-8
5'-O-monomethoxytrityl-O⁴-p-nitrophenylethylthymidine-3'-(2,5-dichlorophenyl,p-nitrophenylethyl)-phosphate

: 87875-22-7
triethylammonium 5'-O-monomethoxytrityl-O⁴-p-nitrophenylethylthymidine-3'-p-nitrophenylethylphosphate

Guidance literature:: DOI:10.1016/S0040-4039(00)88175-7

Reference yield:

: 20264-96-4
2-(4-nitrophenyl)ethyl iodide

: 87875-22-7
triethylammonium 5'-O-monomethoxytrityl-O⁴-p-nitrophenylethylthymidine-3'-p-nitrophenylethylphosphate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) silver carbonate / 1.) benzene, reflux, 1 h; 2.) 50 deg C, 3 d

2: 80 percent / satd. ammonia / dioxane; methanol / 18 h / Ambient temperature

3: 1.) 1,2,4-triazole / 1.) pyridine, r.t., 30 min; 2.) 3.5 h

4: 1.) p-nitrobenzaldoxime / 1.) dioxane, water, 10 min; 2.) 30 min

With 1,2,4-Triazole; ammonia; 4-nitrobenzaldehyde oxime; silver carbonate; In 1,4-dioxane; methanol;
DOI:10.1016/0040-4020(84)85103-0

Reference yield:

: 20264-95-3
2-(4-nitrophenyl)ethyl chloride

: 87875-22-7
triethylammonium 5'-O-monomethoxytrityl-O⁴-p-nitrophenylethylthymidine-3'-p-nitrophenylethylphosphate

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / NaI / butan-2-one / 24 h / Heating

2: 1.) silver carbonate / 1.) benzene, reflux, 1 h; 2.) 50 deg C, 3 d

3: 80 percent / satd. ammonia / dioxane; methanol / 18 h / Ambient temperature

4: 1.) 1,2,4-triazole / 1.) pyridine, r.t., 30 min; 2.) 3.5 h

5: 1.) p-nitrobenzaldoxime / 1.) dioxane, water, 10 min; 2.) 30 min

With 1,2,4-Triazole; ammonia; sodium iodide; 4-nitrobenzaldehyde oxime; silver carbonate; In 1,4-dioxane; methanol; butanone;
DOI:10.1016/0040-4020(84)85103-0