Technology Process of 1,4-Dioxa-8-azaspiro[4.6]undecan-9-one, 8-methyl-
There total 3 articles about 1,4-Dioxa-8-azaspiro[4.6]undecan-9-one, 8-methyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1 ,4-dioxa-8-azaspiro[4,6]undecan-9-one;
With
potassium tert-butylate;
In
toluene;
at 20 ℃;
for 1.5h;
Inert atmosphere;
methyl iodide;
In
toluene;
for 1h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: methanesulfonyl chloride; water; sodium hydrogencarbonate / dichloromethane / 48 h / 0 - 20 °C
2.1: potassium tert-butylate / toluene / 1.5 h / 20 °C / Inert atmosphere
2.2: 1 h / Inert atmosphere
With
potassium tert-butylate; water; sodium hydrogencarbonate; methanesulfonyl chloride;
In
dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / water; dichloromethane / 12 h / 20 °C / Inert atmosphere; Large scale
2.1: methanesulfonyl chloride; water; sodium hydrogencarbonate / dichloromethane / 48 h / 0 - 20 °C
3.1: potassium tert-butylate / toluene / 1.5 h / 20 °C / Inert atmosphere
3.2: 1 h / Inert atmosphere
With
hydroxylamine hydrochloride; potassium tert-butylate; water; sodium hydrogencarbonate; methanesulfonyl chloride;
In
dichloromethane; water; toluene;
