4-Thiazoleacetic acid, 2-[[2-[[[(2S)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]- 2-oxoethyl]thio]-

Base Information

Chemical Name:4-Thiazoleacetic acid, 2-[[2-[[[(2S)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]- 2-oxoethyl]thio]-
CAS No.:879399-82-3
Molecular Formula:C19H21Cl2N3O4S2
Molecular Weight:490.431
Hs Code.:

Synonyms:

Suppliers and Price of 4-Thiazoleacetic acid, 2-[[2-[[[(2S)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]- 2-oxoethyl]thio]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Thiazoleacetic acid, 2-[[2-[[[(2S)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]- 2-oxoethyl]thio]-

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

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Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-Thiazoleacetic acid, 2-[[2-[[[(2S)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]- 2-oxoethyl]thio]-

There total 6 articles about 4-Thiazoleacetic acid, 2-[[2-[[[(2S)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]- 2-oxoethyl]thio]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 879402-30-9
(2S)-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}chloroacetamide

: 38449-49-9
2-mercapto-thiazole-4-acetic acid,ethyl ester

: 879399-82-3
(2S)-[4-(carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide

Guidance literature:: 2-mercapto-thiazole-4-acetic acid,ethyl ester; With sodium hydroxide; water; tert-butyl alcohol; for 1.5h;

(2S)-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}chloroacetamide; In tert-butyl methyl ether; water; tert-butyl alcohol; at 65 ℃; for 6h;

With hydrogenchloride; water; Product distribution / selectivity;

Reference yield:

: 879402-33-2
(2S)-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}-2-[4-(ethoxycarbonylmethyl)thiazol-2-ylthio]acetamide

: 879399-82-3
(2S)-[4-(carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide

Guidance literature:: (2S)-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}-2-[4-(ethoxycarbonylmethyl)thiazol-2-ylthio]acetamide; With methanol; sodium hydroxide; water; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; water; In tetrahydrofuran; Product distribution / selectivity;

Reference yield:

: 610305-43-6
2-{[(2R)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}-1H-isoindole-1,3-(2H)-dione

: 879399-82-3
(2S)-[4-(carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine / ethanol / 0.1 h / Large scale

2.1: toluene; ethanol / 1.13 h / Large scale

3.1: potassium hydroxide / tert-butyl methyl ether; water / 0.33 h / Large scale

3.2: 0.37 h / Large scale

4.1: sodium hydroxide / water; tert-butyl alcohol / 1.25 h / Large scale

4.2: Large scale

With potassium hydroxide; sodium hydroxide; hydrazine; In ethanol; tert-butyl methyl ether; water; toluene; tert-butyl alcohol;