(2S)-[4-(carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide hydrobromide

Base Information

• Chemical Name: (2S)-[4-(carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide hydrobromide
• CAS No.: 1002092-12-7
• Molecular Formula: BrH*C₁₉H₂₁Cl₂N₃O₄S₂
• Molecular Weight: 571.343
• Mol file: 1002092-12-7.mol

Synonyms:(2S)-[4-(carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide hydrobromide

Chemical Property of (2S)-[4-(carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-[4-(carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide hydrobromide

There total 5 articles about (2S)-[4-(carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-[4-(carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide (879399-82-3) → (2S)-[4-(carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide hydrobromide (1002092-12-7)

Guidance literature:

In water; acetone; at 0 - 20 ℃; for 3h;

Reference yield:

(2S)-2-aminomethyl-4-(3,4-dichlorobenzyl)morpholine oxalate → (2S)-[4-(carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide hydrobromide (1002092-12-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide / tert-butyl methyl ether; water / 0.33 h / Large scale

1.2: 0.37 h / Large scale

2.1: sodium hydroxide / water; tert-butyl alcohol / 1.25 h / Large scale

2.2: Large scale

3.1: hydrogen bromide / tert-butyl alcohol; acetonitrile / 0.33 h / Large scale

With hydrogen bromide; potassium hydroxide; sodium hydroxide; In tert-butyl methyl ether; water; acetonitrile; tert-butyl alcohol;

Reference yield:

2-{[(2R)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}-1H-isoindole-1,3-(2H)-dione (610305-43-6) → (2S)-[4-(carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide hydrobromide (1002092-12-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrazine / ethanol / 0.1 h / Large scale

2.1: toluene; ethanol / 1.13 h / Large scale

3.1: potassium hydroxide / tert-butyl methyl ether; water / 0.33 h / Large scale

3.2: 0.37 h / Large scale

4.1: sodium hydroxide / water; tert-butyl alcohol / 1.25 h / Large scale

4.2: Large scale

5.1: hydrogen bromide / tert-butyl alcohol; acetonitrile / 0.33 h / Large scale

With hydrogen bromide; potassium hydroxide; sodium hydroxide; hydrazine; In ethanol; tert-butyl methyl ether; water; toluene; acetonitrile; tert-butyl alcohol;

upstream raw materials:

(2S)-[4-(carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide

2-{[(2R)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}-1H-isoindole-1,3-(2H)-dione

(2S)-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}chloroacetamide

2-mercapto-thiazole-4-acetic acid,ethyl ester