Chemical Property of Artesunato
Chemical Property:
- Appearance/Colour:white crystalline powder
- Melting Point:132-135 °C
- Refractive Index:1.543
- Boiling Point:502.1 °C at 760 mmHg
- PKA:4.28±0.17(Predicted)
- Flash Point:173.5 °C
- PSA：100.52000
- Density:1.31 g/cm3
- LogP:2.60240
- Storage Temp.:Room temp
- Solubility.:acetone: soluble33.4mg/mL
- XLogP3:2.5
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:5
- Exact Mass:384.17841785
- Heavy Atom Count:27
- Complexity:623
- Purity/Quality:
-
98.00% *data from raw suppliers
Artesunate *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xn
- Statements:
20/21/22
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC(=O)CCC(=O)O)C
- Recent ClinicalTrials:Artesunate Suppositories for the Treatment of HIV-negative Patients With Intra-anal HSIL
- Recent EU Clinical Trials:PHASE I-II EFFICACY-TOXICITY OF ARTESUNATE IN FRIEDREICH ATAXIA
-
Uses
Artesunate is a kind of anti-malarial drug that has a relative strong killing effect on the asexual body of plasmodium falciparum and can result in rapid control of malaria episodes.Artesunate is dispensed as a powder of artesunic acid. This is dissolved in sodium bicarbonate (5%) to form sodium artesunate. The solution is then diluted in approximately 5 ml of 5% dextrose and given by intravenous injection or by intramuscular injection to the anterior thigh. The solution should be prepared freshly for each administration and should not be stored. Artesunate, a semi-synthetic artemisinin derivative, has been shown to be effective against parasites, such as liver flukes, and has also shown cytotoxic effects on different types of tumor cell lines. artesunate belong to Antimalarial which is clinically useful for treatment of malaria and other parasitic diseases.
