3-Heptanone, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-hydroxy-1-[(4-methoxyphenyl) methoxy]-6-methyl-1-[(1R,2R)-2-methylcyclopropyl]-, (1S,5S,6S)-

Base Information

Chemical Name:3-Heptanone, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-hydroxy-1-[(4-methoxyphenyl) methoxy]-6-methyl-1-[(1R,2R)-2-methylcyclopropyl]-, (1S,5S,6S)-
CAS No.:879873-86-6
Molecular Formula:C26H44O5Si
Molecular Weight:464.718
Hs Code.:

3-Heptanone,
7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-hydroxy-1-[(4-methoxyphenyl)
methoxy]-6-methyl-1-[(1R,2R)-2-methylcyclopropyl]-, (1S,5S,6S)-

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Chemical Property of 3-Heptanone, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-hydroxy-1-[(4-methoxyphenyl) methoxy]-6-methyl-1-[(1R,2R)-2-methylcyclopropyl]-, (1S,5S,6S)-

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Technology Process of 3-Heptanone, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-hydroxy-1-[(4-methoxyphenyl) methoxy]-6-methyl-1-[(1R,2R)-2-methylcyclopropyl]-, (1S,5S,6S)-

There total 8 articles about 3-Heptanone, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-hydroxy-1-[(4-methoxyphenyl) methoxy]-6-methyl-1-[(1R,2R)-2-methylcyclopropyl]-, (1S,5S,6S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 879873-85-5
4-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)butan-2-one

: 104701-87-3
(2S)-3-(tert-butyl-dimethyl-silyloxy)-2-methyl-propanal

: 879873-86-6
7-(tert-butyldimethylsilanyloxy)-5-hydroxy-1-(4-methoxybenzyloxy)-6-methyl-1-(2-methylcyclopropyl)heptan-3-one

Guidance literature:: 4-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)butan-2-one; (2S)-3-(tert-butyl-dimethyl-silyloxy)-2-methyl-propanal; With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In diethyl ether; at -78 ℃; for 2h;

With dihydrogen peroxide; In methanol; ethanol; at 20 ℃; for 1h; pH=7;
DOI:10.1021/ol052851n

Reference yield:

: 879873-84-4
1-Methoxy-4-[(S)-3-methyl-1-((1R,2R)-2-methyl-cyclopropyl)-but-3-enyloxymethyl]-benzene

: 879873-86-6
7-(tert-butyldimethylsilanyloxy)-5-hydroxy-1-(4-methoxybenzyloxy)-6-methyl-1-(2-methylcyclopropyl)heptan-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; O₃ / methanol / -78 °C

1.2: 96 percent / Me₂S / methanol / 4 h / -78 - 20 °C

2.1: iPr₂NEt; Bu₂BOTf / diethyl ether / 2 h / -78 °C

2.2: 93 percent / H₂O₂ / ethanol; methanol / 1 h / 20 °C / pH 7

With pyridine; di-n-butylboryl trifluoromethanesulfonate; ozone; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; 2.1: aldol reaction;
DOI:10.1021/ol052851n

Reference yield:

: 879873-83-3
4-(2-bromomethylcyclopropyl)-4-(4-methoxybenzyloxy)-2-methyl-1-butene

: 879873-86-6
7-(tert-butyldimethylsilanyloxy)-5-hydroxy-1-(4-methoxybenzyloxy)-6-methyl-1-(2-methylcyclopropyl)heptan-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96 percent / LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

2.1: pyridine; O₃ / methanol / -78 °C

2.2: 96 percent / Me₂S / methanol / 4 h / -78 - 20 °C

3.1: iPr₂NEt; Bu₂BOTf / diethyl ether / 2 h / -78 °C

3.2: 93 percent / H₂O₂ / ethanol; methanol / 1 h / 20 °C / pH 7

With pyridine; lithium aluminium tetrahydride; di-n-butylboryl trifluoromethanesulfonate; ozone; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; 3.1: aldol reaction;
DOI:10.1021/ol052851n