879873-85-5

Upstream product

• 956143-73-0 C₉H₁₇NO₃C₇H₆OCH₂ 
• 676-58-4 methylmagnesium chloride 
• 408348-31-2 (1R,2R)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 879873-81-1 4-(2-[tert-butyldiphenylsilanyloxymethyl]cyclopropyl)-4-(4-methoxybenzyloxy)-2-methyl-1-butene 
• 879873-80-0 (S)-1-[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-cyclopropyl]-3-methyl-but-3-en-1-ol 
• 879873-82-2 {(1R,2R)-2-[(S)-1-(4-Methoxy-benzyloxy)-3-methyl-but-3-enyl]-cyclopropyl}-methanol 
• 879873-83-3 4-(2-bromomethylcyclopropyl)-4-(4-methoxybenzyloxy)-2-methyl-1-butene 
• 956143-68-3 C₁₆H₁₉NO₄CH₂ 
• 906645-20-3 (S)-3-(methoxy(methyl)amino)-1-((1R,2R)-2-methylcyclopropyl)-3-oxopropyl acetate 
• 906645-21-4 (S)-3-hydroxy-N-methoxy-N-methyl-3-[(1R,2R)-2-methylcyclopropyl]propanamide 
• 956143-40-1 (R)-3-hydroxy-N-methoxy-N-methyl-3-((1R,2R)-2-methylcyclopropyl)propanamide 
• 879873-84-4 1-Methoxy-4-[(S)-3-methyl-1-((1R,2R)-2-methyl-cyclopropyl)-but-3-enyloxymethyl]-benzene 

Downstream Products

• 879873-94-6 {(2S,3S,4S,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-[(S)-2-(4-methoxy-benzyloxy)-2-((1R,2R)-2-methyl-cyclopropyl)-ethyl]-3-methyl-tetrahydro-pyran-2-yl}-acetic acid methyl ester 
• 879873-88-8 4-[1-(tert-butyldimethylsilanyloxymethyl)ethyl]-6-[2-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)ethyl]-2,2-dimethyl-[1,3]dioxan 
• 879873-87-7 (1S,3S,5S,6S)-7-(tert-Butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-6-methyl-1-((1R,2R)-2-methyl-cyclopropyl)-heptane-3,5-diol 
• 879873-91-3 (E)-(S)-4-{(4S,6R)-6-[(S)-2-(4-Methoxy-benzyloxy)-2-((1R,2R)-2-methyl-cyclopropyl)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-pent-2-enoic acid methyl ester 
• 879873-93-5 {4-hydroxy-6-[2-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)ethyl]-3-methyltetrahydropyran-2-yl}acetic acid methyl ester 
• 879873-92-4 5,7-dihydroxy-9-(4-methoxybenzyloxy)-4-methyl-9-(2-methylcyclopropyl)non-2-enoic acid methyl ester 
• 879873-89-9 (S)-2-{(4S,6R)-6-[(S)-2-(4-Methoxy-benzyloxy)-2-((1R,2R)-2-methyl-cyclopropyl)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-propan-1-ol 
• 879873-90-2 2-{6-[2-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)ethyl]-2,2-dimethyl[1,3]dioxan-4-yl}propionaldehyde 
• 879873-86-6 7-(tert-butyldimethylsilanyloxy)-5-hydroxy-1-(4-methoxybenzyloxy)-6-methyl-1-(2-methylcyclopropyl)heptan-3-one 

Relevant academic research and scientific papers

Enantioselective total synthesis of (-)-Clavosolide A and B

Enantioselective total synthesis of (-)-clavosolide A and B was reported in full including the synthesis of proposed structure of (-)-clavosoldie A (1), revised structure of (-)-clavosoldie A (5), and revised structure of (-)-clavosoldie B (6). The relative and absolute stereochemistries of the natural products were confirmed unambiguously by comparing the optical rotation values and 1H and 13C NMR spectra of them.

Enantioselective total synthesis of (-)-clavosolide B

Enantioselective synthesis of 2, a revised structure for (-)-clavosolide B, was accomplished by a convergent approach, where syn-selective aldol, hydroxy-directed cyclopropanation, Mitsunobu inversion, Schmidt-type glycosylation, and macrolactonization re

Total synthesis, structural revision, and absolute configuration of (+)-clavosolide A

Enantioselective synthesis of 3, a revised structure for clavosolide A, was completed. Both 1H and 13C NMR spectra of the natural and synthetic compounds were identical, and optical rotation measurements identified the absolute confi